Emergence and Spread of Carbapenem-Resistant and Aminoglycoside-Panresistant Enterobacter cloacae Complex Isolates Coproducing NDM-Type Metallo-β-Lactamase and 16S rRNA Methylase in Myanmar.

Autor: Oshiro S; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan., Tada T; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan., Watanabe S; Department of Microbiome Research, Juntendo University School of Medicine, Tokyo, Japan., Tohya M; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan., Hishinuma T; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan., Uchida H; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan., Kuwahara-Arai K; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan., Mya S; National Health Laboratory, Yangon, Myanmar., Zan KN; National Health Laboratory, Yangon, Myanmar., Kirikae T; Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan t-kirikae@juntendo.ac.jp., Tin HH; National Health Laboratory, Yangon, Myanmar.
Jazyk: angličtina
Zdroj: MSphere [mSphere] 2020 Mar 11; Vol. 5 (2). Date of Electronic Publication: 2020 Mar 11.
DOI: 10.1128/mSphere.00054-20
Abstrakt: Surveillance of 10 hospitals and a regional public health laboratory in Myanmar identified 31 isolates of carbapenem-resistant Enterobacter cloacae complex harboring bla NDM-type Of these isolates, 19 were highly resistant to aminoglycosides and harbored one or more genes encoding 16S rRNA methylases, including armA , rmtB , rmtC , and/or rmtE Of the 19 isolates, 16 were Enterobacter xiangfangensis ST200, with armA on the chromosome and a plasmid harboring bla NDM-1 and rmtC , indicating that these isolates were clonally disseminated nationwide in Myanmar. IMPORTANCE The emergence of multidrug-resistant E. cloacae complex has become a public health threat worldwide. E. xiangfangensis is a recently classified species belonging to E. cloacae complex. Here, we report a clonal dissemination of multidrug-resistant E. xiangfangensis ST200 producing two types of New Delhi metallo-β-lactamase (NDM-type MBL), NDM-1 and -4, and three types of 16S rRNA methylases, ArmA, RmtC, and RmtE, in hospitals in Myanmar. The observation of these multidrug-resistant E. xiangfangensis ST200 isolates stresses the urgency to continue molecular epidemiological surveillance of these pathogens in Myanmar and in South Asian countries.
(Copyright © 2020 Oshiro et al.)
Databáze: MEDLINE
Externí odkaz: