In RRP, serologic response to HPV is frequently absent and slow to develop.

Autor: Buchinsky FJ; Respiratory Papillomatosis Program, Allegheny Health Network, Pittsburgh, Pennsylvania, United States of America., Ruszkay N; Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America., Valentino W; Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America., Derkay CS; Department of Otolaryngology Head Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia, United States of America., McClay JE; Frisco ENT for Children, Dallas, Texas, United States of America., Bastian RW; Bastian Voice Institute, Downers Grove, Illinois, United States of America., Myer CM; Department of Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America., Lollar KW; Ear, Nose, & Throat Center of the Ozarks, Springdale, Arkansas, United States of America., Guris D; Merck & Co., Inc., (MSD), North Wales, Pennsylvania, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Mar 11; Vol. 15 (3), pp. e0230106. Date of Electronic Publication: 2020 Mar 11 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0230106
Abstrakt: Background: Recurrent respiratory papillomatosis (RRP) is characterized by repeated formation of papillomas in the respiratory tract and is caused by human papillomavirus (HPV) types 6 and 11. Women with genital HPV infection are slow to develop weak humoral immunity, but respond robustly to the HPV vaccine. We wondered if people with RRP had a similar immune response.
Methods: A convenience cross-sectional sample of patients with RRP were recruited into one of four groups: 1) adults and adolescents with active RRP, 2) children with active RRP, 3) RRP patients who had undergone HPV vaccination prior to enrollment and, 4) people with RRP who were in remission. Anti-HPV6 and HPV11 serology was determined by cLIA on a single blood draw.
Results: Of the 70 subjects enrolled, 36, 16, 8, and 10, were in groups 1, 2, 3, and 4, respectively. 47% of participants aged >11 years and 81% aged ≤11 years possessed no antibodies against HPV6 or HPV11 (ie. double seronegative). 61% of patients in remission were double seronegative. All participants who had received HPV vaccine previously were seropositive to at least one of these low risk HPV types (ie none of them were double seronegative). Among patients who had active RRP and never had HPV vaccination (n = 52) there was an association between duration of symptoms and seropositivity. Of those who were seropositive, the geometric mean duration of symptoms was 11 years compared to 4.7 years for those who were seronegative (p = 0.001).
Conclusion: People with RRP are capable of developing a humoral response to HPV6 and HPV11. That response appears to be robust when initiated by the HPV vaccine, but either nonexistent or slow to develop in response to infection. Most in remission do not have demonstrable antibody levels against HPV6 or HPV11.
Competing Interests: The authors of have read the journal's policy and the authors of this manuscript have the following competing interests: FB was awarded research funding to conduct the study. He has received no funding since the study was executed and initially reported in 2011. There is no ongoing employment, consultancy, patent or product relationship with MSD. DG is a paid employee, and Executive Director of MSD. MSD tested the serum samples and provided funding. JM is a co-owner of Frisco ENT for Children (http://friscoentforchildren.com/). RB is the majority owner of Bastian Voice Institute (https://www.bastianvoice.com/). KL is a partner of Ear, Nose &Throat Center of the Ozarks (https://entozarks.com/). There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The opinions expressed in this paper are those of the authors and do not necessarily represent those of MSD.
Databáze: MEDLINE
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