| Autor: |
Nikitina MP; Research Institute of Human Morphology, Moscow, Russia., Elchaninov AV; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. elchandrey@yandex.ru.; Peoples' Friendship University of Russia, Moscow, Russia. elchandrey@yandex.ru., Lokhonina AV; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; Peoples' Friendship University of Russia, Moscow, Russia., Makarov AV; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Tagirova MK; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia., Grinberg MV; Peoples' Friendship University of Russia, Moscow, Russia., Bolshakova GB; Research Institute of Human Morphology, Moscow, Russia., Glinkina VV; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Goldshtein DV; N. P. Bochkov Research Center for Medical Genetics, Moscow, Russia., Fatkhudinov TK; Research Institute of Human Morphology, Moscow, Russia.; Peoples' Friendship University of Russia, Moscow, Russia. |
| Abstrakt: |
Differences in the gene expression profiles in resident macrophages (in particular, Kupffer cells) and monocytes were revealed. However, these differences in gene expression profiles do not allow considering resident liver macrophages as purely M2 macrophages and monocytes as purely M1 macrophages. At the same time, a significant number of the genes upregulated in Kupffer cells are associated with normal regulation of liver functions (Arg 1, Flt, iNOs, and Kng). In monocytes, the expression of genes Alox15, Alox12, Tlr2, Tlr4, Tlr7, and Tlr8 (typical functional genes of macrophages) was also upregulated in comparison with Kupffer cells. |
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