AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.

Autor:	Acevedo-Jake A; Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K., Ball AT; Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K., Galli M; Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K., Kukwikila M; Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K., Denis M; Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K., Singleton DG; ATDBio Ltd, School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K., Tavassoli A; Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K., Goldup SM; Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
Jazyk:	angličtina
Zdroj:	Journal of the American Chemical Society [J Am Chem Soc] 2020 Apr 01; Vol. 142 (13), pp. 5985-5990. Date of Electronic Publication: 2020 Mar 20.
DOI:	10.1021/jacs.0c01670
Abstrakt:	We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
Databáze:	MEDLINE
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