Cardiac iron concentration in relation to systemic iron status and disease severity in non-ischaemic heart failure with reduced ejection fraction.

Autor: Hirsch VG; Division of Molecular and Translational Cardiology, Hannover Medical School, Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Tongers J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Bode J; Institute for Analytical Chemistry, University of Mining and Technology, Freiberg, Germany., Berliner D; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Widder JD; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Escher F; Institute for Cardiac Diagnostics and Therapy, Berlin, Germany., Mutsenko V; Institute for Multiphase Processes, Leibniz University, Hannover, Germany., Chung B; Division of Molecular and Translational Cardiology, Hannover Medical School, Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Rostami F; Division of Molecular and Translational Cardiology, Hannover Medical School, Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Guba-Quint A; Division of Molecular and Translational Cardiology, Hannover Medical School, Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Giannitsis E; Cardiology, Department of Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany., Schultheiss HP; Institute for Cardiac Diagnostics and Therapy, Berlin, Germany., Vogt C; Institute for Analytical Chemistry, University of Mining and Technology, Freiberg, Germany., Bauersachs J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Wollert KC; Division of Molecular and Translational Cardiology, Hannover Medical School, Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Kempf T; Division of Molecular and Translational Cardiology, Hannover Medical School, Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Jazyk: angličtina
Zdroj: European journal of heart failure [Eur J Heart Fail] 2020 Nov; Vol. 22 (11), pp. 2038-2046. Date of Electronic Publication: 2020 Mar 10.
DOI: 10.1002/ejhf.1781
Abstrakt: Aims: Low cardiac iron levels promote heart failure in experimental models. While cardiac iron concentration (CI) is decreased in patients with advanced heart failure with reduced ejection fraction (HFrEF), CI has never been measured in non-advanced HFrEF. We measured CI in left ventricular (LV) endomyocardial biopsies (EMB) from patients with non-advanced HFrEF and explored CI association with systemic iron status and disease severity.
Methods and Results: We enrolled 80 consecutive patients with non-ischaemic HFrEF with New York Heart Association class II or III symptoms and a median (interquartile range) LV ejection fraction of 25 (18-33)%. CI was 304 (262-373) μg/g dry tissue. CI was not related to immunohistological findings or the presence of cardiotropic viral genomes in EMBs and was not related to biomarkers of systemic iron status or anaemia. Patients with CI in the lowest quartile (CI Q1 ) had lower body mass indices and more often presented with heart failure histories longer than 6 months than patients in the upper three quartiles (CI Q2-4 ). CI Q1 patients had higher serum N-terminal pro-B-type natriuretic peptide levels than CI Q2-4 patients [3566 (1513-6412) vs. 1542 (526-2811) ng/L; P = 0.005]. CI Q1 patients also had greater LV end-diastolic (P = 0.001) and end-systolic diameter indices (P = 0.003) and higher LV end-diastolic pressures (P = 0.046) than CI Q2-4 patients.
Conclusion: Low CI is associated with greater disease severity in patients with non-advanced non-ischaemic HFrEF. CI is unrelated to systemic iron homeostasis. The prognostic and therapeutic implications of CI measurements in EMBs should be further explored.
(© 2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje