Parental and life-course influences on symptomatic airflow obstruction.

Autor:	Li LSK; School of Health Sciences, University of South Australia, Adelaide, Australia., Williams MT; School of Health Sciences, University of South Australia, Adelaide, Australia., Johnston KN; School of Health Sciences, University of South Australia, Adelaide, Australia., Frith P; School of Health Sciences, University of South Australia, Adelaide, Australia.; College of Medicine and Public Health, Flinders University, Adelaide, Australia., Hyppönen E; School of Health Sciences, University of South Australia, Adelaide, Australia., Paquet C; School of Health Sciences, University of South Australia, Adelaide, Australia.
Jazyk:	angličtina
Zdroj:	ERJ open research [ERJ Open Res] 2020 Mar 02; Vol. 6 (1). Date of Electronic Publication: 2020 Mar 02 (Print Publication: 2020).
DOI:	10.1183/23120541.00343-2019
Abstrakt:	Few studies have examined the contribution of life-course factors in explaining familial aggregation of chronic lung conditions. Using data from the 1958 British Birth Cohort, a life-course approach was used to examine whether, and how, exposure to risk factors through one's life explained the association between parental respiratory disease history and symptomatic airflow obstruction (AO). Cohort participants (n=6212) were characterised in terms of parental respiratory disease history and symptomatic AO at 45 years. Life-course factors ( e.g. smoking, asthma and early-life factors) were operationalised as life period-specific and cumulative measures. Logistic regression and path analytic models predicting symptomatic AO adjusted for parental respiratory disease history were used to test different life-course models (critical period, accumulation- and chain-of-risks models). While some life-course factors ( e.g. childhood passive smoking and occupational exposure) were individually associated with parental respiratory disease history and symptomatic AO, asthma (OR 6.44, 95% CI 5.01-8.27) and persistent smoking in adulthood (OR 5.42, 95% CI 4.19-7.01) had greater impact on the association between parental respiratory disease history and symptomatic AO. A critical period model provided a better model fit compared with an accumulation-of-risk model and explained 57% of the effect of parental respiratory disease history on symptomatic AO. Adulthood asthma and smoking status explained around half of the effect of parental respiratory disease history on chronic obstructive pulmonary disease. Beyond smoking history, the combination of parental respiratory disease history and adulthood asthma may provide an opportunity for early diagnosis and intervention. Competing Interests: Conflict of interest: L.S.K. Li reports an Australian Government Research Training Program Scholarship during the conduct of the study and grants from the Physiotherapy Research Foundation outside the submitted work. Conflict of interest: M.T. Williams reports grants from the Medical Research Future Fund Rapid Applied Research Translation Impact Grant Scheme and the Physiotherapy Research Foundation, outside the submitted work. Conflict of interest: K.N. Johnston has nothing to disclose. Conflict of interest: P. Frith has nothing to disclose. Conflict of interest: E. Hyppönen has nothing to disclose. Conflict of interest: C. Paquet has nothing to disclose. (Copyright ©ERS 2020.)
Databáze:	MEDLINE
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