A 3D-Printed Hybrid Nasal Cartilage with Functional Electronic Olfaction.

Autor: Jodat YA; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA.; Department of Mechanical Engineering Stevens Institute of Technology Hoboken NJ 07030 USA., Kiaee K; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA.; Department of Mechanical Engineering Stevens Institute of Technology Hoboken NJ 07030 USA., Vela Jarquin D; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA.; Instituto Tecnológico y de Estudios Superiores de Monterrey Calle del Puente #222 Col. Ejidos de Huipulco, Tlalpan C.P. 14380 México D.F. Mexico., De la Garza Hernández RL; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA.; Instituto Tecnológico y de Estudios Superiores de Monterrey Av. Eugenio Garza Sada 2501 Sur, Tecnológico 64849 Monterrey N.L. Mexico., Wang T; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA.; School of Medicine Jiangsu University Zhenjiang Jiangsu 212013 China., Joshi S; Department of Mechanical Engineering Stevens Institute of Technology Hoboken NJ 07030 USA., Rezaei Z; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA.; Department of Chemical and Petroleum Engineering Sharif University of Technology Azadi Ave 11365-11155 Tehran Iran., de Melo BAG; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA.; Department of Engineering of Materials and Bioprocesses School of Chemical Engineering University of Campinas Campinas São Paulo 13083-852 Brazil., Ge D; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA., Mannoor MS; Department of Mechanical Engineering Stevens Institute of Technology Hoboken NJ 07030 USA., Shin SR; Division of Engineering in Medicine Department of Medicine Harvard Medical School Brigham and Women's Hospital Cambridge MA 02139 USA.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2020 Jan 10; Vol. 7 (5), pp. 1901878. Date of Electronic Publication: 2020 Jan 10 (Print Publication: 2020).
DOI: 10.1002/advs.201901878
Abstrakt: Advances in biomanufacturing techniques have opened the doors to recapitulate human sensory organs such as the nose and ear in vitro with adequate levels of functionality. Such advancements have enabled simultaneous targeting of two challenges in engineered sensory organs, especially the nose: i) mechanically robust reconstruction of the nasal cartilage with high precision and ii) replication of the nose functionality: odor perception. Hybrid nasal organs can be equipped with remarkable capabilities such as augmented olfactory perception. Herein, a proof-of-concept for an odor-perceptive nose-like hybrid, which is composed of a mechanically robust cartilage-like construct and a biocompatible biosensing platform, is proposed. Specifically, 3D cartilage-like tissue constructs are created by multi-material 3D bioprinting using mechanically tunable chondrocyte-laden bioinks. In addition, by optimizing the composition of stiff and soft bioinks in macro-scale printed constructs, the competence of this system in providing improved viability and recapitulation of chondrocyte cell behavior in mechanically robust 3D constructs is demonstrated. Furthermore, the engineered cartilage-like tissue construct is integrated with an electrochemical biosensing system to bring functional olfactory sensations toward multiple specific airway disease biomarkers, explosives, and toxins under biocompatible conditions. Proposed hybrid constructs can lay the groundwork for functional bionic interfaces and humanoid cyborgs.
Competing Interests: The authors declare no conflict of interest.
(© 2020 Brigham and Women's Hospital/Harvard Medical School. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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