Cardiotoxicity and cardiovascular disease risk assessment for patients receiving breast cancer treatment.

Autor: Clark RA; 1College of Nursing and Health Sciences, Flinders University, Adelaide, SA Australia., Marin TS; 1College of Nursing and Health Sciences, Flinders University, Adelaide, SA Australia., Berry NM; 2Norwich Medical School, University of East Anglia, James Watson Road, Norwich Research Park, Norwich, NR4 7UQ UK., Atherton JJ; 3Head Cardiology Royal Brisbane and Women's Hospital, University of Queensland School of Medicine, Butterfield St & Bowen Bridge Rd, Herston, St Lucia, QLD Australia., Foote JW; 1College of Nursing and Health Sciences, Flinders University, Adelaide, SA Australia., Koczwara B; 4Department of Medical Oncology, Flinders Centre for Innovation in Cancer, Flinders University, Flinders Drive, Bedford Park, SA 5042 Australia.
Jazyk: angličtina
Zdroj: Cardio-oncology (London, England) [Cardiooncology] 2017 Oct 17; Vol. 3, pp. 6. Date of Electronic Publication: 2017 Oct 17 (Print Publication: 2017).
DOI: 10.1186/s40959-017-0025-7
Abstrakt: Background: Cardiotoxicity from anticancer therapy affects heart function and structure. Cardiotoxicity can also lead to accelerated development of chronic diseases, especially in the presence of risk factors.
Methods: This study aimed to develop and pilot a combined cardiovascular disease and cardiotoxicity risk assessment questionnaire to quantify the potential extent of risk factors in breast cancer patients prior to treatment. The questionnaire underwent content and face validity evaluation by an expert panel followed by pilot testing in a sample of breast cancer patients ( n  = 36). Questionnaires were self-administered while attending chemotherapy clinic, in the presence of a research assistant.
Results: Mean age of participants was 54.8 years (range 36-72 years). Participants reported CVD risk factors including diabetes 2.8%, hypertension 19.8%, hypercholesterolaemia 11% and sleep apnoea 5%. Lifestyle risk factors, included not eating the recommended serves of vegetables (100%) or fruit (78%) per day; smoking (13%) and regularly consuming alcohol (75%). Twenty five percent reported being physically inactive, 61%, overweight or obese, 24%, little or no social support and 30% recorded high to very high psychological distress. Participants were highly (75%) reluctant to undertake lifestyle changes; i.e. changing alcohol consumption; dietary habits; good emotional/mental health strategies; improving physical activity; quitting smoking; learning about heart-health and weight loss.
Conclusion: This study is an important step towards prevention and management of treatment-associated cardiotoxicity after breast cancer diagnosis. We recommend that our questionnaire is providing important data that should be included in cancer registries so that researchers can establish the relationship between CVD risk profile and cardiotoxicity outcomes and that this study revealed important teaching opportunities that could be used to examine the impact on health literacy and help patients better understand the consequences of cancer treatment.
Competing Interests: Competing interestsThe authors state that the proposed publication does not concern any commercial product, either directly or indirectly. All authors declare that they have no conflict of interest.
(© The Author(s). 2017.)
Databáze: MEDLINE
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