Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model.

Autor: Akinnuga AM; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South Africa., Siboto A; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South Africa., Khumalo B; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South Africa., Sibiya NH; Department of Pharmacy and Pharmacology, Rhodes University, Grahamstown, South Africa., Ngubane P; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South Africa., Khathi A; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Nata, Westville, Durban, South Africa.
Jazyk: angličtina
Zdroj: Canadian journal of gastroenterology & hepatology [Can J Gastroenterol Hepatol] 2020 Feb 20; Vol. 2020, pp. 2475301. Date of Electronic Publication: 2020 Feb 20 (Print Publication: 2020).
DOI: 10.1155/2020/2475301
Abstrakt: Background: Prediabetes is an intermediary hyperglycaemic state that precedes type 2 diabetes mellitus (T2DM) in which abnormal metabolism of glucose and lipids occurs in organs such as the liver. Evidence has shown that, about 70% of T2DM patients develop hepatic dysfunction which is found to begin during the prediabetic stage. Bredemolic acid, a pentacyclic triterpene, has been found to improve insulin sensitivity in diet-induced prediabetic rats. The effects of this compound on liver function, however, are unknown. This study was therefore designed to investigate the effects of BA on liver function in high fat-high carbohydrate (HFHC) diet-induced prediabetic rats.
Methods: Thirty-six (36) male rats that weigh 150 g-180 g were divided into two groups, the non-prediabetic ( n  = 6) and the prediabetic groups ( n  = 6) and the prediabetic groups ( n  = 6) and the prediabetic groups (.
Results: The induction of prediabetes resulted in increased release of liver enzymes (AST and ALT), increased liver glycogen and triglyceride, lipid peroxidation, and decreased sterol regulatory element-binding protein (SREBP1c) and antioxidant enzymes. However, the administration of BA decreased liver enzyme concentrations, decreased hepatic oxidative stress, and improved antioxidant enzymes such as SOD and GPx.
Conclusion: BA administration improved liver function in diet-induced prediabetic rats in the presence or absence of dietary intervention.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2020 Akinjide Moses Akinnuga et al.)
Databáze: MEDLINE
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