Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link.

Autor:	Brzecka A; Department of Pulmonology and Lung Cancer, Wroclaw Medical University, Wroclaw, Poland., Madetko N; Department of Neurology, Wroclaw Medical University, Wroclaw, Poland., Nikolenko VN; I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Str., Moscow, 119991, Russian Federation., Ashraf GM; King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia., Ejma M; Department of Neurology, Wroclaw Medical University, Wroclaw, Poland., Leszek J; Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland., Daroszewski C; Department of Pulmonology and Lung Cancer, Wroclaw Medical University, Wroclaw, Poland., Sarul K; Department of Pulmonology and Lung Cancer, Wroclaw Medical University, Wroclaw, Poland., Mikhaleva LM; Research Institute of Human Morphology,3 Tsyurupy Street, Moscow, 117418, Russian Federation., Somasundaram SG; Department of Biological Sciences, Salem University, Salem, WV, 26426, United States., Kirkland CE; Department of Biological Sciences, Salem University, Salem, WV, 26426, United States., Bachurin SO; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, 142432, Russian Federation., Aliev G; I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Str., Moscow, 119991, Russian Federation.
Jazyk:	angličtina
Zdroj:	Current neuropharmacology [Curr Neuropharmacol] 2021; Vol. 19 (1), pp. 78-91.
DOI:	10.2174/1570159X18666200309101750
Abstrakt:	There is an increasing number of patients worldwide with sleep disturbances and diabetes. Various sleep disorders, including long or short sleep duration and poor sleep quality of numerous causes, may increase the risk of diabetes. Some symptoms of diabetes, such as painful peripheral neuropathy and nocturia, or associated other sleep disorders, such as sleep breathing disorders or sleep movement disorders, may influence sleep quality and quantity. Both sleep disorders and diabetes may lead to cognitive impairment. The risk of development of cognitive impairment in diabetic patients may be related to vascular and non-vascular and other factors, such as hypoglycemia, hyperglycemia, central insulin resistance, amyloid and tau deposits and other causes. Numerous sleep disorders, e.g., sleep apnea, restless legs syndrome, insomnia, and poor sleep quality are most likely are also associated with cognitive impairment. Adequate functioning of the system of clearance of the brain from toxic substances, such as amyloid β, i.e. glymphatic system, is related to undisturbed sleep and prevents cognitive impairment. In the case of coexistence, sleep disturbances and diabetes either independently lead to and/or mutually aggravate cognitive impairment. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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