| Autor: |
Kudryashov NV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. kunvi@mail.ru.; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. kunvi@mail.ru., Ivanova EA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Kalinina TS; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Shimshirt AA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Kurshin AA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Zhmurenko LA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia., Voronina TA; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. |
| Abstrakt: |
It was shown that finasteride, a 5α-reductase inhibitor (50 mg/kg, intraperitoneally) produced analgesic and antiexudative effects in experimental peritonitis induced by intraperitoneal injection of 1% acetic acid. These results agree with published data on its anti-inflammatory properties and ability to potentiate the analgesic effect of morphine in rodents. New pyrazolo[C] pyridine derivative GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,3-dihydro-1H-pyrazolo[4,3-C]pyridine-3-on, chloral hydrate) injected intraperitoneally in doses of 20-80 mg/kg produced dose-dependent antiexudative effects, but exhibited no analgesic properties. |
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