Impairment of myocardial functions and arterial stiffness in patients with lichen planus.

Autor:	Baykal Selcuk L; Department of Dermatology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey. Electronic address: dr.leylabaykal@gmail.com., Sahin M; Department of Dermatology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey., Arıca DA; Department of Dermatology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey., Orem A; Department of Biochemistry, Karadeniz Technical University, School of Medicine, Trabzon, Turkey., Karaca Ural Z; Department of Dermatology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey., Yaylı S; Department of Dermatology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
Jazyk:	angličtina
Zdroj:	Anais brasileiros de dermatologia [An Bras Dermatol] 2020 Mar - Apr; Vol. 95 (2), pp. 180-186. Date of Electronic Publication: 2020 Feb 12.
DOI:	10.1016/j.abd.2019.07.005
Abstrakt:	Background: Lichen planus is a chronic inflammatory mucocutaneous disease. Recent studies have suggested that it is associated with an increased risk of cardiovascular comorbidities. Objective: The purpose of this study was to assess and compare arterial stiffness and cardiovascular hemodynamics in patients with lichen planus and a healthy control group. Methods: Fifty-five patients with lichen planus and 42 healthy controls were enrolled. All patients underwent echocardiographic examination, and arterial stiffness was measured using applanation tonometry. Results: No statistically significant difference was determined between the patient and control groups in terms of arterial stiffness, but stiffness was markedly higher in patients with erosive lichen planus compared to the control group and other patients (p=0.006, and p=0.023, respectively). Moderate positive correlation was determined between duration of disease and arterial stiffness. Impairment of systolic and diastolic functions was also determined in patients with lichen planus compared to the control group (p<0.001, and p=0.005, respectively). Study Limitations: Relatively low number of patients. Conclusion: The positive correlation observed between duration of disease and arterial stiffness in patients with lichen planus suggests that these patients should be followed-up in terms of cardiovascular risk in the presence of resistant and long-term disease, particularly in case of erosive lichen planus. (Copyright © 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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