Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group.

Autor:	Chinn GA; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA., Pearn ML; Department of Anesthesiology, University of California, San Diego, CA, USA., Vutskits L; Department of Anesthesiology, Clinical Pharmacology, Intensive Care and Emergency Medicine, University Hospitals of Geneva, Geneva, Switzerland., Mintz CD; Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Loepke AW; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Lee JJ; Department of Anesthesiology, Columbia University, New York, NY, USA., Chen J; Department of Anesthesiology, Columbia University, New York, NY, USA., Bosnjak ZJ; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA., Brambrink AM; Department of Anesthesiology, Columbia University, New York, NY, USA., Jevtovic-Todorovic V; Department of Anesthesiology, University of Colorado, Aurora, CO, USA., Sun LS; Department of Anesthesiology, Columbia University, New York, NY, USA., Sall JW; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA. Electronic address: Jeffrey.Sall@ucsf.edu.
Jazyk:	angličtina
Zdroj:	British journal of anaesthesia [Br J Anaesth] 2020 May; Vol. 124 (5), pp. 585-593. Date of Electronic Publication: 2020 Mar 04.
DOI:	10.1016/j.bja.2020.01.011
Abstrakt:	In March 2019, SmartTots, a public-private partnership between the US Food and Drug Administration and the International Anesthesia Research Society, hosted a meeting attended by research experts, anaesthesia journal editors, and government agency representatives to discuss the continued need for rigorous preclinical research and the importance of establishing reporting standards for the field of anaesthetic perinatal neurotoxicity. This group affirmed the importance of preclinical research in the field, and welcomed novel and mechanistic approaches to answer some of the field's largest questions. The attendees concluded that summarising the benefits and disadvantages of specific model systems, and providing guidance for reporting results, would be helpful for designing new experiments and interpreting results across laboratories. This expert opinion report is a summary of these discussions, and includes a focused review of current animal models and reporting standards for the field of perinatal anaesthetic neurotoxicity. This will serve as a practical guide and road map for novel and rigorous experimental work. (Copyright © 2020 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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