Effects of High-Intensity Interval Training After Stroke (the HIIT-Stroke Study): A Multicenter Randomized Controlled Trial.

Autor: Gjellesvik TI; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Physical Medicine and Rehabilitation, St Olav's University Hospital, Trondheim, Norway. Electronic address: tor.i.gjellesvik@ntnu.no., Becker F; Department of Research, Sunnaas Rehabilitation Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Faculty of Medicine, Oslo, Norway., Tjønna AE; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; NeXt Move, NTNU, Trondheim, Norway., Indredavik B; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Stroke Unit, Department of Internal Medicine, St Olav's University Hospital, Trondheim, Norway., Nilsen H; Department of Physical Medicine and Rehabilitation, Ålesund Hospital, Ålesund, Norway., Brurok B; Department of Physical Medicine and Rehabilitation, St Olav's University Hospital, Trondheim, Norway; Centre for Elite Sports Research, Department of Neuromedicine and Movement Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Tørhaug T; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Physical Medicine and Rehabilitation, St Olav's University Hospital, Trondheim, Norway., Busuladzic M; Department of Research, Sunnaas Rehabilitation Hospital, Oslo, Norway., Lydersen S; Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Trondheim, Norway., Askim T; Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Science, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Stroke Unit, Department of Internal Medicine, St Olav's University Hospital, Trondheim, Norway.
Jazyk: angličtina
Zdroj: Archives of physical medicine and rehabilitation [Arch Phys Med Rehabil] 2020 Jun; Vol. 101 (6), pp. 939-947. Date of Electronic Publication: 2020 Mar 04.
DOI: 10.1016/j.apmr.2020.02.006
Abstrakt: Objective: To examine if 8 weeks of high-intensity interval training (HIIT) in addition to standard care would increase and maintain peak oxygen uptake (Vo 2peak ) more than standard care alone in patients with stroke.
Design: This was a single-blind, multicenter, parallel group, randomized controlled trial.
Setting: Specialized rehabilitation units at 3 Norwegian hospitals.
Participants: Participants (N=70), 3 months to 5 years after first-ever stroke, were randomly assigned to the intervention group (n=36) or the control group (n=34); 42% were women, mean age was 57.6±9.3 years, mean time post stroke was 26.4±14.5 months.
Intervention: The intervention was 8 weeks: 3 times a week with HIIT treadmill training with work periods of 4 × 4 minutes at 85%-95% of peak heart rate interspersed with 3 minutes of active recovery at 50%-70% of peak heart rate. The control group received standard care according to national guidelines.
Outcomes: The primary outcome, analyzed by intention-to-treat, was Vo 2peak measured as liters per minute 12 months after inclusion. Secondary outcome measures were blood pressure and blood profile.
Results: Mean baseline Vo 2peak was 2.63±1.08 L·min -1 vs 2.87±0.71 L·min -1 , while at 12 months Vo 2peak was 2.70±1.00 L·min -1 vs 2.67±0.76 L·min -1 (P=.068) in the intervention and control groups, respectively. There was a significant and greater improvement in the intervention group compared with the control group at 12 months in 3 of 6 secondary outcomes from the peak test but no significant differences for blood pressure or blood profile.
Conclusions: The HIIT intervention, which was well-tolerated in this sample of well-functioning survivors of stroke, was not superior to standard care in improving and maintaining Vo 2peak at the 12-month follow-up. However, secondary results from the peak test showed a significant improvement from before to immediately after the intervention.
(Copyright © 2020 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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