Typical and atypical carcinoid tumors of the lung: a clinicopathological correlation of 783 cases with emphasis on histological features.

Autor: Moran CA; Department of Pathology, MD Anderson Cancer Center, Houston, TX, 77030, USA. Electronic address: cesarmoran@mdanderson.org., Lindholm KE; Department of Pathology, MD Anderson Cancer Center, Houston, TX, 77030, USA., Brunnström H; Lund University, Laboratory Medicine, Department of Clinical Sciences Lund, Pathology, Lund, 22210, Sweden., Langman G; Heart of England NHS Foundation Trust, Birmingham, B1 1BB, United Kingdom., Jang SJ; Asan Medical Center, Ulsan University School of Medicine, Seoul, 100-011, Republic of Korea., Spagnolo D; PathWest Laboratory Medicine Western Australia, University of Western Australia, School of Pathology and Laboratory Medicine, Nedlands, Western Australia, 6006, Australia; University of Notre Dame, Fremantle, Western Australia, 6006, Australia., Chai SM; PathWest Laboratory Medicine Western Australia, University of Western Australia, School of Pathology and Laboratory Medicine, Nedlands, Western Australia, 6006, Australia., Laycock A; PathWest Laboratory Medicine Western Australia, University of Western Australia, School of Pathology and Laboratory Medicine, Nedlands, Western Australia, 6006, Australia; University of Notre Dame, Fremantle, Western Australia, 6006, Australia., Falconieri G; General University Hospital, Udine, 33100, Italy., Pizzolitto S; General University Hospital, Udine, 33100, Italy., de Pellegrin A; General University Hospital, Udine, 33100, Italy., Medeiros F; Essex Cardiothoracic Center, Basildon, CB1 6NU, United Kingdom; Thurrock University Hospitals NHS Foundation Trust, RM16 4XS, United Kingdom., Edmunds L; Essex Cardiothoracic Center, Basildon, CB1 6NU, United Kingdom; Thurrock University Hospitals NHS Foundation Trust, RM16 4XS, United Kingdom., Catarino A; Hospital da Luz, Lisboa, Portugal., Cunha F; Portuguese Institute of Oncology, Lisbon, Portugal., Ro J; Methodist Hospital, Houston, TX, 77030, USA., Pina-Oviedo S; University of Arkansas for Medical Sciences, Little Rock AK, 72701, USA., Torrealba J; UT Southwestern, Dallas, TX, 75390, USA., Coppola D; Moffitt Cancer Center in Tampa, Florida, 33612, USA., Petersson F; National University Hospital, 119260, Singapore., Oon ML; National University Hospital, 119260, Singapore., Elmberger G; Umea University Hospital, Umea, 90130, Sweden., Y Cajal SR; Vall D'Hebron University Hospital, Barcelona, 08001, Spain., Valero IS; Vall D'Hebron University Hospital, Barcelona, 08001, Spain., Dalurzo L; Hospital Italiano de Buenos Aires, B11675, Argentina., Soares F; A. C. Camargo Cancer Center, Sao Paulo, 01000-000, Brazil., Campos AH; A. C. Camargo Cancer Center, Sao Paulo, 01000-000, Brazil., Vranic S; Qatar University College of Medicine, Qatar., Skenderi F; University of Sarajevo Clinical Center, 71000, Sarajevo., Correa AM; Department of Thoracic Surgery, M D Anderson Cancer Center, Houston, TX, 77030, USA., Sepesi B; Department of Thoracic Surgery, M D Anderson Cancer Center, Houston, TX, 77030, USA., Rice D; Department of Thoracic Surgery, M D Anderson Cancer Center, Houston, TX, 77030, USA., Mehran R; Department of Thoracic Surgery, M D Anderson Cancer Center, Houston, TX, 77030, USA., Walsh G; Department of Thoracic Surgery, M D Anderson Cancer Center, Houston, TX, 77030, USA.
Jazyk: angličtina
Zdroj: Human pathology [Hum Pathol] 2020 Apr; Vol. 98, pp. 98-109. Date of Electronic Publication: 2020 Mar 05.
DOI: 10.1016/j.humpath.2020.02.005
Abstrakt: We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the different parameters evaluated. Of the histopathological features analyzed, the presence of mitotic activity of 4 mitoses or more per 2 mm 2 , necrosis, lymphatic invasion, and lymph node metastasis were identified as statistically significant. Tumors measuring 3 cm or more were also identified as statistically significant and correlated with clinical outcomes. Based on our analysis, we consider that the separation of low- and intermediate-grade neuroendocrine neoplasms of the lung needs to be readjusted in terms of mitotic count as the risk of overgrading these neoplasms exceeds 10% under the current criteria. We also consider that tumor size is an important feature to be considered in the assessment of these neoplasms and together with the histological grade of the tumor offers important features that can be correlated with clinical outcomes.
(Crown Copyright © 2020. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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