| Autor: |
Gorshunova NK; Kursk State Medical University, 3 K.Marx str., Kursk 305041, Russian Federation, e-mail: gorsh@kursknet.ru., Savich VV; Kursk State Medical University, 3 K.Marx str., Kursk 305041, Russian Federation, e-mail: gorsh@kursknet.ru. |
| Jazyk: |
ruština |
| Zdroj: |
Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2019; Vol. 32 (5), pp. 765-770. |
| Abstrakt: |
Metabolic disorders of the interstitial heart and vessels matrix in hypertension develop due to chronic stretching of their walls. For estimation the involutive and hypertensive changes in interstitial matrix of the heart and vessels we have been examined 30 normotensive elderly women and 30 patients of same age with arterial hypertension (AH) II stage, as well as the possibility of their correction by valsartan and veroshpiron. The next parameters of investigation used: the volume fraction of interstitial collagen (VFIC) in myocardium, cardiovascular conjugation (CVC), serum concentrations of markers of systemic collagenogenesis - COL-1, TGF-β1, MMP-1, TIMP-1, Gal-3. CVC reflected the hard-elastic properties of the myocardium and arterial vessels, which was elevated in women with AH. A high intensity of LV myocardial fibrosis was revealed with a significant increase in the VFIC content in elderly patients with AH compared with normotensive patients. This is due to the increased activity of fibrosis markers. There was a decrease in their level after antihypertensive therapy, which proved its antifibrotic effect. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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