First report of equine parvovirus-hepatitis-associated Theiler's disease in Europe.

Autor: Vengust M; University of Ljubljana, Veterinary Faculty, Ljubljana, Slovenia., Jager MC; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Zalig V; University of Ljubljana, Veterinary Faculty, Ljubljana, Slovenia.; Marc Veterinary Services, Sezana, Slovenia., Cociancich V; University of Ljubljana, Veterinary Faculty, Ljubljana, Slovenia., Laverack M; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Renshaw RW; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Dubovi E; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Tomlinson JE; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Van de Walle GR; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Divers TJ; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Jazyk: angličtina
Zdroj: Equine veterinary journal [Equine Vet J] 2020 Nov; Vol. 52 (6), pp. 841-847. Date of Electronic Publication: 2020 Mar 25.
DOI: 10.1111/evj.13254
Abstrakt: Background: Equine parvovirus-hepatitis (EqPV-H) has been proposed as the aetiological cause of Theiler's disease, also known as serum hepatitis. EqPV-H-associated Theiler's disease has not been previously reported in Europe.
Objectives: To determine whether EqPV-H infection was associated with a 2018-2019 outbreak of Theiler's disease in four horses on a studfarm.
Study Design: Descriptive case series.
Methods: The medical records of four horses from the same farm diagnosed with fatal Theiler's disease were examined retrospectively. Information collected included a clinical history, physical examination findings, tetanus antitoxin exposure, serum biochemistry and necropsy reports. Liver tissue from all four horses was tested for EqPV-H using PCR and in situ hybridisation (ISH) assays.
Results: Three of the horses had a history of recent (7-11 weeks) tetanus antitoxin administration. Liver tissue from all four horses tested positive for EqPV-H with PCR. In situ hybridisation revealed a widespread distribution of viral nucleic acid in hepatocytes in one case, and a more sporadic distribution in the remaining three cases.
Main Limitations: Case controls were not available from the farm in question given the retrospective nature of analysis.
Conclusions: This case series documents the first reported EqPV-H-associated Theiler's disease in Europe and the first use of ISH to visualise the viral nucleic acid in liver tissues of horses with Theiler's disease.
(© 2020 EVJ Ltd.)
Databáze: MEDLINE
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