Central neurogenetic signatures of the visuomotor integration system.

Autor:	Bueichekú E; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115.; Department of Basic Psychology, Clinical Psychology and Psychobiology, Jaume I University, 12071 Castelló de la Plana, Spain., Aznárez-Sanado M; Neuroimaging Laboratory, School of Medicine, University of Navarra, 31008 Pamplona, Spain.; School of Education and Psychology, University of Navarra, 31008 Pamplona, Spain., Diez I; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115.; Neurotechnology Laboratory, Health Department, Tecnalia, E-48160 Derio, Spain., d'Oleire Uquillas F; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08540.; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129., Ortiz-Terán L; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115.; Department of Radiology, Brigham and Women's Hospital, Boston MA 02115., Qureshi AY; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129.; Department of Neurology, University of Kansas Medical Center, Kansas City, MO 66160., Suñol M; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115.; Psychiatry Department, Bellvitge University Hospital, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L'Hospitalet de Llobregat, Barcelona, Spain.; Center for Biomedical Research in Mental Health Network, Carlos III Health Institute, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.; Department of Clinical Sciences, School of Medicine, University of Barcelona, 08036 Barcelona, Spain., Basaia S; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115.; Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, 20132 Milan, Italy., Ortiz-Terán E; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115., Pastor MA; Neuroimaging Laboratory, School of Medicine, University of Navarra, 31008 Pamplona, Spain., Sepulcre J; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115; sepulcre@nmr.mgh.harvard.edu.; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 24; Vol. 117 (12), pp. 6836-6843. Date of Electronic Publication: 2020 Mar 06.
DOI:	10.1073/pnas.1912429117
Abstrakt:	Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader-Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. We found the genetic expression of four genes-TBR1, SCN1A, MAGEL2, and CACNB4-to be prominently associated with visuomotor integrators in the human cortex. TBR1 gene transcripts, an ASD gene whose expression is related to neural development of the cortex and the hippocampus, showed a central spatial allocation within the VMI system. Our findings delineate gene expression traits underlying the VMI system in the human cortex, where specific genes, such as TBR1, are likely to play a central role in its neuronal organization, as well as on specific phenotypes of neurogenetic syndromes. Competing Interests: The authors declare no competing interest.
Databáze:	MEDLINE
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