Systems analysis and improvement approach to optimize the hypertension diagnosis and care cascade for PLHIV individuals (SAIA-HTN): a hybrid type III cluster randomized trial.

Autor: Gimbel S; Department of Child, Family and Population Health Nursing, University of Washington School of Nursing, 1959 NE Pacific St, Seattle, WA, 98195, USA. sgimbel@uw.edu.; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA. sgimbel@uw.edu.; Health Alliance International (HAI), 1107 NE 45th St, Suite 350, Seattle, WA, 98105, USA. sgimbel@uw.edu., Mocumbi AO; Faculty of Medicine, Eduardo Mondlane University, Avenida Salvador Allende, 702, Maputo, Mozambique., Ásbjörnsdóttir K; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA.; Health Alliance International, Caixa Postal, #23, Maputo, Mozambique., Coutinho J; Department of Epidemiology, University of Washington School of Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Andela L; Beira Central Hospital, Beira, Mozambique., Cebola B; Beira Central Hospital, Beira, Mozambique., Craine H; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Crocker J; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Hicks L; Health Alliance International (HAI), 1107 NE 45th St, Suite 350, Seattle, WA, 98105, USA., Holte S; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Hossieke R; Manica Provincial Health Department, Chimoio, Mozambique., Itai E; Sofala Provincial Health Department, Beira, Mozambique., Levin C; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Manaca N; Department of Epidemiology, University of Washington School of Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Murgorgo F; Manica Provincial Health Department, Chimoio, Mozambique., Nhumba M; Department of Epidemiology, University of Washington School of Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Pfeiffer J; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA.; Health Alliance International (HAI), 1107 NE 45th St, Suite 350, Seattle, WA, 98105, USA., Ramiro I; Department of Epidemiology, University of Washington School of Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Ronen K; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Sotoodehnia N; Department of Cardiology, University of Washington School of Medicine, 325 9th Avenue, Seattle, WA, 98104, USA., Uetela O; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Wagner A; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Weiner BJ; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA., Sherr K; Department of Global Health, University of Washington Schools of Medicine and Public Health, 1705 NE Pacific St, Seattle, WA, 98195, USA.; Health Alliance International (HAI), 1107 NE 45th St, Suite 350, Seattle, WA, 98105, USA.
Jazyk: angličtina
Zdroj: Implementation science : IS [Implement Sci] 2020 Mar 06; Vol. 15 (1), pp. 15. Date of Electronic Publication: 2020 Mar 06.
DOI: 10.1186/s13012-020-0973-4
Abstrakt: Background: Across sub-Saharan Africa, evidence-based clinical guidelines to screen and manage hypertension exist; however, country level application is low due to lack of service readiness, uneven health worker motivation, weak accountability of health worker performance, and poor integration of hypertension screening and management with chronic care services. The systems analysis and improvement approach (SAIA) is an evidence-based implementation strategy that combines systems engineering tools into a five-step, facility-level package to improve understanding of gaps (cascade analysis), guide identification and prioritization of low-cost workflow modifications (process mapping), and iteratively test and redesign these modifications (continuous quality improvement). As hypertension screening and management are integrated into chronic care services in sub-Saharan Africa, an opportunity exists to test whether SAIA interventions shown to be effective in improving efficiency and coverage of HIV services can be effective when applied to the non-communicable disease services that leverage the same platform. We hypothesize that SAIA-hypertension (SAIA-HTN) will be effective as an adaptable, scalable model for broad implementation.
Methods: We will deploy a hybrid type III cluster randomized trial to evaluate the impact of SAIA-HTN on hypertension management in eight intervention and eight control facilities in central Mozambique. Effectiveness outcomes include hypertension cascade flow measures (screening, diagnosis, management, control), as well as hypertension and HIV clinical outcomes among people living with HIV. Cost-effectiveness will be estimated as the incremental costs per additional patient passing through the hypertension cascade steps and the cost per additional disability-adjusted life year averted, from the payer perspective (Ministry of Health). SAIA-HTN implementation fidelity will be measured, and the Consolidated Framework for Implementation Research will guide qualitative evaluation of the implementation process in high- and low-performing facilities to identify determinants of intervention success and failure, and define core and adaptable components of the SAIA-HTN intervention. The Organizational Readiness for Implementing Change scale will measure facility-level readiness for adopting SAIA-HTN.
Discussion: SAIA packages user-friendly systems engineering tools to guide decision-making by front-line health workers to identify low-cost, contextually appropriate chronic care improvement strategies. By integrating SAIA into routine hypertension screening and management structures, this pragmatic trial is designed to test a model for national scale-up.
Trial Registration: ClinicalTrials.gov NCT04088656 (registered 09/13/2019; https://clinicaltrials.gov/ct2/show/NCT04088656).
Databáze: MEDLINE
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