Brain-predicted age difference score is related to specific cognitive functions: a multi-site replication analysis.

Autor: Boyle R; Trinity College Institute of Neuroscience, Trinity College Dublin, Lloyd Building, Dublin 2, Ireland., Jollans L; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, München, Germany., Rueda-Delgado LM; Trinity College Institute of Neuroscience, Trinity College Dublin, Lloyd Building, Dublin 2, Ireland., Rizzo R; Physics Department, University of Calabria, Rende, CS, Italy., Yener GG; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, İzmir, Turkey.; Department of Neurology, Dokuz Eylul University Medical School, İzmir, Turkey.; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylul University, İzmir, Turkey., McMorrow JP; Centre for Advanced Medical Imaging, St. James's Hospital, Dublin 8, Ireland.; School of Medicine, Trinity College Dublin, Dublin 2, Ireland., Knight SP; School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin 2, Ireland., Carey D; The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin 2, Ireland.; Department of Medical Gerontology, Trinity College Dublin, Dublin 2, Ireland., Robertson IH; Trinity College Institute of Neuroscience, Trinity College Dublin, Lloyd Building, Dublin 2, Ireland.; Global Brain Health Institute, Trinity College Dublin, Lloyd Building, Dublin 2, Ireland., Emek-Savaş DD; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, İzmir, Turkey.; Global Brain Health Institute, Trinity College Dublin, Lloyd Building, Dublin 2, Ireland.; Department of Psychology, Faculty of Letters, Dokuz Eylul University, İzmir, Turkey., Stern Y; Cognitive Neuroscience Division, Department of Neurology, Columbia University, New York, NY, USA., Kenny RA; School of Medicine, Trinity College Dublin, Dublin 2, Ireland.; The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin 2, Ireland.; Mercer's Institute for Successful Ageing, St. James's Hospital, Dublin 8, Ireland., Whelan R; Trinity College Institute of Neuroscience, Trinity College Dublin, Lloyd Building, Dublin 2, Ireland. robert.whelan@tcd.ie.; Global Brain Health Institute, Trinity College Dublin, Lloyd Building, Dublin 2, Ireland. robert.whelan@tcd.ie.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2021 Feb; Vol. 15 (1), pp. 327-345.
DOI: 10.1007/s11682-020-00260-3
Abstrakt: Brain-predicted age difference scores are calculated by subtracting chronological age from 'brain' age, which is estimated using neuroimaging data. Positive scores reflect accelerated ageing and are associated with increased mortality risk and poorer physical function. To date, however, the relationship between brain-predicted age difference scores and specific cognitive functions has not been systematically examined using appropriate statistical methods. First, applying machine learning to 1359 T1-weighted MRI scans, we predicted the relationship between chronological age and voxel-wise grey matter data. This model was then applied to MRI data from three independent datasets, significantly predicting chronological age in each dataset: Dokuz Eylül University (n = 175), the Cognitive Reserve/Reference Ability Neural Network study (n = 380), and The Irish Longitudinal Study on Ageing (n = 487). Each independent dataset had rich neuropsychological data. Brain-predicted age difference scores were significantly negatively correlated with performance on measures of general cognitive status (two datasets); processing speed, visual attention, and cognitive flexibility (three datasets); visual attention and cognitive flexibility (two datasets); and semantic verbal fluency (two datasets). As such, there is firm evidence of correlations between increased brain-predicted age differences and reduced cognitive function in some domains that are implicated in cognitive ageing.
Databáze: MEDLINE
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