Isolated tumor cells in the regional lymph nodes in patients with squamous cell carcinoma of the esophagus are rarely observed but often represent part of a true metastasis.

Autor: Jepsen DNM; Department of Pathology, University Hospital of Copenhagen, Rigshospitalet, Frederik V's Vej 11, 2100 Copenhagen, Denmark; Department of Pathology, University Hospital of Copenhagen, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark. Electronic address: dea.natalie.munch.jepsen@regionh.dk., Fiehn AK; Department of Pathology, University Hospital of Copenhagen, Rigshospitalet, Frederik V's Vej 11, 2100 Copenhagen, Denmark. Electronic address: anne-marie.kanstrup.fiehn.01@regionh.dk., Svendsen B; Department of Pathology, University Hospital of Copenhagen, Rigshospitalet, Frederik V's Vej 11, 2100 Copenhagen, Denmark. Electronic address: bonnie.svendsen@regionh.dk., Achiam MP; Department of Surgical Gastroenterology, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: michael.patrick.achiam.01@regionh.dk., Federspiel B; Department of Pathology, University Hospital of Copenhagen, Rigshospitalet, Frederik V's Vej 11, 2100 Copenhagen, Denmark. Electronic address: birgitte.federspiel@regionh.dk.
Jazyk: angličtina
Zdroj: Annals of diagnostic pathology [Ann Diagn Pathol] 2020 Apr; Vol. 45, pp. 151478. Date of Electronic Publication: 2020 Feb 14.
DOI: 10.1016/j.anndiagpath.2020.151478
Abstrakt: The most common malignancy of the esophagus is squamous cell carcinoma (SCC) and regional lymph node metastases are an important prognostic factor. Isolated tumor cells (ITCs) are defined as single tumor cells or small clusters of tumor cells not exceeding 0.2 mm. The prognostic role of ITCs is not clear. This study aimed to determine the prevalence of ITCs in regional lymph nodes in patients with esophageal SCC and to investigate how frequently ITCs represent part of a true metastasis. Surgical specimens from 100 patients with SCC of the esophagus were included. All original H&E stained slides containing lymph nodes were reviewed by two gastrointestinal pathologists. In lymph nodes containing ITCs, additional levels were cut and stained with a H&E- and a cytokeratin stain. Areas of tumor cells that measured >0.2 mm on the deeper sections were classified as metastases. A total of 2460 lymph nodes were examined. ITCs were detected in 10 lymph nodes (0.4%) from nine patients (9%). Deeper sections revealed metastases in five out of the 10 lymph nodes (50%). ITCs in regional lymph nodes of patients with SCC of the esophagus is a rare finding compared with patients with adenocarcinoma of the esophagogastric junction. However, deeper sections often revealed metastases. Therefore, in patients with SCC of the esophagus, we recommend additional sectioning and immunohistochemical examination of lymph nodes when ITCs are detected on the first slide.
Competing Interests: Declaration of competing interest The authors report no conflicts of interest.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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