Double-edged sword of inflammasome genetics in colorectal cancer prognosis.

Autor: Cambui RAG; Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: raylanecambui@gmail.com., do Espírito Santo GF; Instituto de Tumores e Cuidados Paliativos de Cuiabá do Hospital Geral e Maternidade de Cuiabá, Cuiabá, MT, Brazil., Fernandes FP; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil., Leal VNC; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil., Galera BB; Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil., Fávaro EGP; Universidade de Cuiabá, Cuiabá, MT, Brazil., Rizzo LA; Centro Universitário de Várzea Grande, Várzea Grande, MT, Brazil., Elias RM; Centro Universitário de Várzea Grande, Várzea Grande, MT, Brazil., Pontillo A; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Apr; Vol. 213, pp. 108373. Date of Electronic Publication: 2020 Mar 02.
DOI: 10.1016/j.clim.2020.108373
Abstrakt: Inflammation is a colorectal cancer (CRC) hallmark. Inflammasome-dependent cytokines IL-1ß and IL-18 can play a beneficial or detrimental role in tumorigenesis depending on cancer type. Variants in inflammasome genes were associated with tumor development and/or outcome, and have been proposed as potential biomarkers for population screening. In this study, 215 CRC patients followed-up for 10 years were examined for 9 polymorphisms in selected inflammasome genes. Multivariate association analysis and survival analysis were performed to evaluate the association between the polymorphisms and CRC prognosis. Variants associated with lower levels of IL-18 (rs1834481, rs5744256), or with increased activation of inflammasome receptors NLRP1 (rs12150220) and NLRP3 (rs35829419) resulted detrimental to CRC prognosis and may be used as prognostic markers.
Competing Interests: Declaration of Competing Interest On behalf of all authors, the corresponding author states that there is no conflict of interest.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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