A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain.

Autor: Roberson EC; Department of Molecular Biosciences, Patterson Labs, University of Texas at Austin, Austin, Texas, USA., Tran NK; Department of Molecular Biosciences, Patterson Labs, University of Texas at Austin, Austin, Texas, USA., Konjikusic MJ; Department of Molecular Biosciences, Patterson Labs, University of Texas at Austin, Austin, Texas, USA.; Department of Pediatrics, Dell Pediatric Research Institute, University of Texas at Austin, Austin, Texas, USA., Fitch RD; Department of Molecular Biosciences, Patterson Labs, University of Texas at Austin, Austin, Texas, USA., Gray RS; Department of Pediatrics, Dell Pediatric Research Institute, University of Texas at Austin, Austin, Texas, USA.; Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas, USA., Wallingford JB; Department of Molecular Biosciences, Patterson Labs, University of Texas at Austin, Austin, Texas, USA.
Jazyk: angličtina
Zdroj: Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2020 Jul; Vol. 249 (7), pp. 898-905. Date of Electronic Publication: 2020 Mar 12.
DOI: 10.1002/dvdy.165
Abstrakt: Background: In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastly different local environments that may dictate differences in their lifetime and turnover rates. However, with the exception of MCCs in the trachea, the turnover rates of these multiciliated epithelial populations at extended time scales are not well described.
Results: Here, using genetic lineage-labeling techniques we provide a direct comparison of turnover rates of MCCs in these three different tissues.
Conclusion: We find that oviduct turnover is similar to that in the airway (~6 months), while multiciliated ependymal cells turnover more slowly.
(© 2020 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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