Primary Sarcoma of the Lung - Prognostic Value of Clinicopathological Characteristics of 26 Cases.
Autor: | Duran-Moreno J; Fourth Department of Internal Medicine - Hematology Oncology Unit, Attikon University General Hospital, National and Kapodistrian University of Athens, Athens, Greece duranmoreno.jose@gmail.com., Kokkali S; 1st Medical Oncology Clinic, Saint-Savvas Anticancer Hospital, Athens, Greece., Ramfidis V; 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Sotiria General Hospital, Athens, Greece., Salomidou M; Pneumology Department, Saint-Savvas Anticancer Hospital, Athens, Greece., Digklia A; Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Koumarianou A; Fourth Department of Internal Medicine - Hematology Oncology Unit, Attikon University General Hospital, National and Kapodistrian University of Athens, Athens, Greece., Tomos P; Department of Thoracic surgery, Attikon University General Hospital, Athens, Greece., Koufopoulos N; 2nd Pathology Department, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece., Vamvakaris I; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Psychogiou E; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Syrigos K; 3rd Department of Internal Medicine, National and Kapodistrian University of Athens, Sotiria General Hospital, Athens, Greece. |
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Jazyk: | angličtina |
Zdroj: | Anticancer research [Anticancer Res] 2020 Mar; Vol. 40 (3), pp. 1697-1703. |
DOI: | 10.21873/anticanres.14122 |
Abstrakt: | Background/aim: Primary sarcomas of the lung (PSL) represent a rare, largely unknown entity. We herein present a retrospective study of 26 patients diagnosed with PSL. Patients and Methods: For a period of 10 years, the records of patients from 5 centers were gathered and analyzed. Results: Median age at diagnosis was 61.96 years (range=31-75 years). Eight patients (33.33%) had mediastinal node invasion (MNI). From 17 patients (70.83%) with localized disease, 11 patients (64.70%) underwent surgery. Recurrence rate was 72.72%. Median disease-free interval was 15 months. The median overall survival (OS) of patients with metastatic disease was 4 months and 10 months for the whole population. Only surgery had an impact on survival. Conclusion: Prognosis of PSL is somber. The high proportion of patients with MNI at diagnosis may serve as an indication for surgical evaluation of mediastinum and raises the question whether patients with locoregional PSL should be treated with a more aggressive approach. (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) |
Databáze: | MEDLINE |
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