Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study.

Autor:	Mancuzo EV; Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil.; Laboratório de Função Pulmonar, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil., Martins Netto E; Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador (BA) Brasil.; Instituto Brasileiro para a Investigação da Tuberculose - IBIT - Fundação José Silveira, Salvador (BA) Brasil., Sulmonett N; Laboratório de Função Pulmonar, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil., Viana VS; Grupo de Pesquisas em Micobacterioses, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil., Croda J; Faculdade de Ciências da Saúde, Universidade Federal da Grande Dourados, Campo Grande (MS) Brasil., Kritski AL; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil.; Rede Brasileira de Pesquisa em Tuberculose - Rede TB - Rio de Janeiro (RJ) Brasil., Mello FCQ; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil.; Instituto de Doenças do Tórax, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil., Nihues SSE; Curso de Fisioterapia, Centro Universitário da Grande Dourados, Dourados (MS) Brasil., Azevedo KRS; Laboratório de Fisiopatologia Pulmonar, Instituto de Doenças do Tórax, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil., Miranda SS; Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil.; Rede Brasileira de Pesquisa em Tuberculose - Rede TB - Rio de Janeiro (RJ) Brasil.; Ambulatório de Tuberculose e Laboratório de Pesquisa em Micobactérias, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil.
Jazyk:	English; Portuguese
Zdroj:	Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia [J Bras Pneumol] 2020 Mar 02; Vol. 46 (2), pp. e20180198. Date of Electronic Publication: 2020 Mar 02 (Print Publication: 2020).
DOI:	10.36416/1806-3756/e20180198
Abstrakt:	Objective: To compare patients with and without previous lung disease, in terms of the spirometry results after they had been treated for pulmonary tuberculosis (PTB) and cured, as well as to analyze risk factors related to functional severity. Methods: This was a cross-sectional, multicenter study conducted at four referral centers in Brazil. Patients were divided into two groups: those with a history of lung disease or smoking (LDS+ group); and those with no such history (LDS- group). Patients underwent spirometry (at least six months after being cured). Sociodemographic and clinical data were collected. Results: A total of 378 patients were included: 174 (46.1%) in the LDS+ group and 204 (53.9%) in the LDS- group. In the sample as a whole, 238 patients (62.7%) had spirometric changes. In the LDS+ group, there was a predominance of obstructive lung disease (in 33.3%), whereas restrictive lung disease predominated in the LDS- group (in 24.7%). Radiological changes were less common in the LDS- group than in the LDS+ group (p < 0.01), as were functional changes (p < 0.05). However, of the 140 (79.1%) LDS- group patients with a normal or minimally altered chest X-ray, 76 (54%) had functional changes (p < 0.01). The risk factors associated with functional severity in the LDS- group were degree of dyspnea (p = 0.03) and moderate or severe radiological changes (p = 0.01). Conclusions: Impaired pulmonary function is common after treatment for PTB, regardless of the history of lung disease or smoking. Spirometry should be suggested for patients who develop moderate/severe dyspnea or relevant radiological changes after treatment for PTB.
Databáze:	MEDLINE
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