Blood Group Rhesus D-negativity and Awareness Toward Importance of Anti-D Immunoglobulin Among Pregnant Women in Bisha, Saudi Arabia.

Autor:	Yahia A; Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, SAU., Miskeen E; Obstetrics and Gynecology, College of Medicine, University of Bisha, Bisha, SAU., Sohail SK; Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, SAU., Algak T; Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, SAU., Aljadran S; Laboratory Medicine, King Abdullah Hospital, Bisha, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2020 Feb 19; Vol. 12 (2), pp. e7044. Date of Electronic Publication: 2020 Feb 19.
DOI:	10.7759/cureus.7044
Abstrakt:	Background Rhesus D (RhD) antigen alloimmunization has been a focus of concern for hematologists and obstetricians. It contributes to perinatal morbidity and mortality. The objectives of this study were to assess the awareness of pregnant women toward the clinical importance of blood group Rh(D)-negativity and anti-D immunoglobulin and to determine the prevalence of blood group Rh(D)-negativity among them. Methods and materials This cross-sectional study was conducted in a routine antenatal care clinic of King Abdullah Hospital in Bisha, Saudi Arabia from September 2018 to January 2019. The awareness of pregnant women toward the clinical importance of blood group Rh(D)-negativity and prophylaxis with anti-D immunoglobulin was assessed through a self-administered questionnaire. Samples were analyzed for ABO and Rh (D) blood groups using the microplate grouping method. The presence of anti-D alloantibodies was detected by the indirect antiglobulin test. Data were analyzed by IBM SPSS Statistics for Windows, Version 25.0 (Armonk, NY: IBM Corp.). A p-value ≤0.05 was considered statistically significant. Results A total of 108 respondents fulfilled the inclusion criteria and completed the survey. Forty-five pregnant women (41.7%) were observed to be aware of the blood group Rh(D)-negativity and anti-D immunoglobulin issue. The prevalence of the negative blood group was 11.1% (12/108). Awareness was found to be significantly associated with age, education, vaginal bleeding, blood groups, and previous administration of anti-D immunoglobulin (p-value ≤0.05). Conclusion The prevalence of blood group Rh(D)-negativity among respondents was found to be comparative with other populations, although the overall awareness was found to be suboptimal (41.7%). Structured health education programs by hematologists and obstetricians are needed to increase awareness and to address women at reproductive age. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2020, Yahia et al.)
Databáze:	MEDLINE
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