The microbiota of the mother at birth and its influence on the emerging infant oral microbiota from birth to 1 year of age: a cohort study.

Autor: Hurley E; School of Microbiology, University College Cork, Cork, Ireland.; Cork University Dental School & Hospital, Cork University Hospital, Wilton, Cork, Ireland., Mullins D; School of Microbiology, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., Barrett MP; School of Microbiology, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., O'Shea CA; APC Microbiome Ireland, University College Cork, Cork, Ireland.; Department of Neonatology, Cork University Maternity Hospital, Wilton, Cork, Ireland., Kinirons M; Cork University Dental School & Hospital, Cork University Hospital, Wilton, Cork, Ireland., Ryan CA; Department of Neonatology, Cork University Maternity Hospital, Wilton, Cork, Ireland., Stanton C; Teagasc Research Centre Teagasc,, Cork, Fermoy, Ireland., Whelton H; Cork University Dental School & Hospital, Cork University Hospital, Wilton, Cork, Ireland.; College of Medicine and Health, UCC, Cork, Ireland., Harris HMB; School of Microbiology, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland., O'Toole PW; School of Microbiology, University College Cork, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Cork, Ireland.
Jazyk: angličtina
Zdroj: Journal of oral microbiology [J Oral Microbiol] 2019 Apr 26; Vol. 11 (1), pp. 1599652. Date of Electronic Publication: 2019 Apr 26 (Print Publication: 2019).
DOI: 10.1080/20002297.2019.1599652
Abstrakt: Background: The acquisition of microbial communities and the influence of delivery mode on the oral microbiota of the newborn infant remains poorly characterised. Methods: A cohort of pregnant women were enrolled in the study ( n = 84). All infants were born full term, by Spontaneous vaginal delivery (SVD) or by Caesarean section (CS). At delivery a saliva sample along with a vaginal/skin sample from the mother. Saliva samples were the taken from the infant within one week of birth, and at week 4, week 8, 6 months and 1 year of age. We used high-throughput sequencing of V4-V5 region 16S rRNA amplicons to compare the microbiota of all samples. Results: The vaginal microbiota had a lower alpha diversity than the skin microbiota of the mother, while the infant oral microbiota diversity remained relatively stable from birth to 8 weeks of age. The oral microbiota of the neonate differed by birth modality up to 1 week of age ( p < 0.05), but birth modality did not have any influence on the infant oral microbiota beyond this age. Conclusions: We conclude thatbirth mode does not have an effect on the infant oral microbiota beyond 4 weeks of age, and the oral microbiota of infants continues to develop until 1 year of age.
(© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
Databáze: MEDLINE
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