A Europe-wide assessment of antibiotic resistance rates in Bacteroides and Parabacteroides isolates from intestinal microbiota of healthy subjects.

Autor: Sóki J; Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary. Electronic address: soki.jozsef@med.u-szeged.hu., Wybo I; Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium., Hajdú E; Division of Infectious Diseases, First Department of Internal Medicine, Faculty of Medicine, University of Szeged, Szeged, Hungary., Toprak NU; Department of Microbiology, Marmara University Medical School, Istanbul, Turkey., Jeverica S; Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia., Stingu CS; Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University Hospital of Leipzig, Leipzig, Germany., Tierney D; Microbiology Department, Freeman Hospital, Newcastle Upon Tyne, UK., Perry JD; Microbiology Department, Freeman Hospital, Newcastle Upon Tyne, UK., Matuz M; Department of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary., Urbán E; Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary., Nagy E; Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Jazyk: angličtina
Zdroj: Anaerobe [Anaerobe] 2020 Apr; Vol. 62, pp. 102182. Date of Electronic Publication: 2020 Feb 29.
DOI: 10.1016/j.anaerobe.2020.102182
Abstrakt: Here, we sought to assess the levels of antibiotic resistance among intestinal Bacteroides and Parabacteroides strains collected between 2014 and 2016 in Europe and also attempted to compare resistance levels between clinical and commensal isolates. Bacteroides and Parabacteroides isolates were recovered from faecal samples via the novel Bacteroides Chromogenic Agar (BCA) method. Antibiotic susceptibilities were determined by agar dilution for ten antibiotics. The values obtained were then statistically evaluated. Altogether 202 Bacteroides/Parabacteroides isolates (of which 24, 11.9%, were B. fragilis) were isolated from the faecal specimens of individuals taken from five European countries. The percentage values of isolates resistant to ampicillin, amoxicillin/clavulanate, cefoxitin, imipenem, clindamycin, moxifloxacin, metronidazole, tetracycline, tigecycline and chloramphenicol were 96.6, 4.5, 14.9, 2.0, 47.3, 11.4, 0, 66.2, 1.5 and 0%, respectively. These values are close to those reported in the previous European clinical Bacteroides antibiotic susceptibility survey except for amoxicillin/clavulanate and clindamycin, where the former was lower and the latter was higher in normal microbiota isolates. To account for these latter findings and to assess temporal effects we compared the data specific for Hungary for the same period (2014-2016), and we found differences in the resistance rates for cefoxitin, moxifloxacin and tetracycline.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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