Low-Dose Abiraterone in Metastatic Prostate Cancer: Is It Practice Changing? Facts and Facets.

Autor:	Patel A; Malignant Diseases Treatment Centre, Army Hospital Research & Referral, New Delhi, India., Tannock IF; Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada., Srivastava P; M.S. Patel Cancer Center, Shreekrishna Hospital and Research Center, Karamsad, Gujarat, India., Biswas B; Tata Medical Center, Kolkata, India., Gupta VG; Department of Medical Oncology and Hemato-Oncology, Artemis Hospital, Gurugram, Haryana, India., Batra A; All India Institute of Medical Sciences, New Delhi, India., Bhethanabhotla S; Krishna Institute of Medical Sciences, Hyderabad, India., Pramanik R; All India Institute of Medical Sciences, New Delhi, India., Mahindru S; Department of Surgical Oncology, Ivy Hospital, Sahibzada Ajit Singh Nagar, Punjab, India., Tilak T; Department of Internal Medicine, Armed Forces Medical College, Pune, India., Das CK; Regional Cancer Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India., Mehta P; Department of Medical Oncology/Hematology/Bone Marrow Transplantation, Asian Institute of Medical Sciences, Faridabad, Haryana, India.
Jazyk:	angličtina
Zdroj:	JCO global oncology [JCO Glob Oncol] 2020 Mar; Vol. 6, pp. 382-386.
DOI:	10.1200/JGO.19.00341
Abstrakt:	Purpose: It is projected that approximately 50,000 new cases of prostate cancer will be diagnosed in 2020 in India. Survival has improved because of the development of effective drugs such as abiraterone acetate, but universal accessibility to treatment is not always possible because of cost constraints in lower- and middle-income countries. Recently, the National Comprehensive Cancer Network (NCCN) has included low-dose abiraterone (250 mg/day) with food as an alternative treatment option to full-dose abiraterone (1,000 mg/day) fasting. Methods: The Science and Cost Cancer Consortium conducted a survey to evaluate the use of abiraterone in India and the opinions of medical oncologists about using low-dose treatment. Modeling was used to estimate potential financial benefits to individual patients and to estimate overall costs of health care in India if low-dose abiraterone is prescribed. Results: Of 251 Indian medical oncologists who were invited to participate in the survey, 125 provided their e-mail address and received the survey; 118 responded (47% of the total). Of these, 25% were not aware of the recent NCCN recommendation, 55% were already prescribing low-dose abiraterone when resources were limited, 7% had already changed their practice, and 29% agreed to switch to a universal practice of using low-dose abiraterone with food; 9% of practitioners would not use low-dose abiraterone. Estimated mean per patient savings was US$3,640, with annual savings of US$182 million in India. Conclusion: Use of lower-dose abiraterone would increase access to treatment in India and globally and lead to large cost savings.
Databáze:	MEDLINE
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