Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study.

Autor: Wadé NB; Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Cigna Health and Life Insurance Company (Cigna), Bloomfield, CT, USA., Chang CM; Division of Population Health Sciences, Center for Tobacco Products, Food and Drug Administration, Bethesda, MD, USA., Conti D; Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Millstein J; Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Skibola C; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Nieters A; Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, University of Freiburg, Freiburg, Germany., Wang SS; Department of Computational and Quantitative Medicine, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., De Sanjose S; Sexual and Reproductive Health, PATH, Seattle, WA, USA.; Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Kane E; Department of Health Sciences, University of York, York, YO10 5DD, UK., Spinelli JJ; Population Oncology, BC Cancer Agency, Vancouver, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada., Bracci P; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA., Zhang Y; Department of Surgery, Yale School of Medicine and Yale School of Public Health, New Haven, CT, USA., Slager S; Department of Epidemiology, Mayo Clinic, Rochester, MN, USA., Wang J; Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hjalgrim H; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Department of Haematology, Rigshospitalet, Copenhagen, Denmark., Smedby KE; Karolinska Institutet, Sweden University Hospital, Karolinska University, Stockholm, Sweden., Brown EE; Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA., Jarrett RF; MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland., Cozen W; Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. wcozen@med.usc.edu.; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. wcozen@med.usc.edu.; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. wcozen@med.usc.edu.
Jazyk: angličtina
Zdroj: Cancer causes & control : CCC [Cancer Causes Control] 2020 May; Vol. 31 (5), pp. 451-462. Date of Electronic Publication: 2020 Mar 02.
DOI: 10.1007/s10552-020-01266-4
Abstrakt: Purpose: We explored the interaction between non-Hodgkin lymphoma (NHL), infectious mononucleosis (IM) history, and immune-related genotypes in a pooled case-control analysis.
Methods: A total of 7,926 NHL patients and 10,018 controls from 12 case-control studies were included. Studies were conducted during various time periods between 1988 and 2008, and participants were 17-96 years of age at the time of ascertainment/recruitment. Self-reported IM history and immune response genotypes were provided by the InterLymph Data Coordinating Center at Mayo Clinic. Odds ratios (OR) were estimated using multivariate logistic regression, and interactions were estimated using the empirical Bayes method. P ACT was used to account for multiple comparisons.
Results: There was evidence of an interaction effect between IM history and two variants on T-cell lymphoma (TCL) risk: rs1143627 in interleukin-1B (IL1B) (p interaction  = 0.04, OR interaction  = 0.09, 95% confidence interval [CI] 0.01, 0.87) and rs1800797 in interleukin-6 (IL6) (p interaction  = 0.03, OR interaction  = 0.08, 95% CI 0.01, 0.80). Neither interaction effect withstood adjustment for multiple comparisons. There were no statistically significant interactions between immune response genotypes and IM on other NHL subtypes.
Conclusions: Genetic risk variants in IL1B and IL6 may affect the association between IM and TCL, possibly by influencing T-cell activation, growth, and differentiation in the presence of IM, thereby decreasing risk of immune cell proliferation.
Databáze: MEDLINE
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