Treatment Outcomes in Trigeminal Neuralgia-A Systematic Review of Domains, Dimensions and Measures.
| Autor: | Nova CV; UCL Eastman Dental Institute, London, United Kingdom., Zakrzewska JM; UCL Eastman Dental Institute, London, United Kingdom., Baker SR; School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom., Riordain RN; UCL Eastman Dental Institute, London, United Kingdom.; Department of Oral Medicine, Cork University Dental School and Hospital, Cork, Ireland. |
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| Jazyk: | angličtina |
| Zdroj: | World neurosurgery: X [World Neurosurg X] 2020 Jan 27; Vol. 6, pp. 100070. Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020). |
| DOI: | 10.1016/j.wnsx.2020.100070 |
| Abstrakt: | Background: Trigeminal neuralgia (TN) is a painful disorder characterized by sudden electric shock-like pain. It is a rare condition for which multiple treatments are available, including medical and surgical. The best treatment option is yet to be defined, and this is related to the lack of definition in the treatment outcomes and outcome measures. The aim of this systematic review was to summarize all the outcomes and outcomes measures that have been published to date and highlight variability in their use. Methods: We have conducted a literature search using a wide range of databases (1946-2019 for medical and 2008-2019 for surgical treatment), for all intervention studies in TN. Four hundred and sixty-seven studies were selected for data extraction on TN classification, data collection method, intervention, and treatment outcomes mapped to the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT guidelines). Results: Most studies collected data on pain ( n = 459) and side effects ( n = 386) domains; however, very few collected data on the impact of treatment on physical ( n = 46) and emotional functioning ( n = 17) and on patient satisfaction ( n = 35). There was high variability on outcome measures used for pain relief ( n = 10), pain intensity ( n = 9), and frequency of pain episodes ( n = 3). Conclusions: A clear definition of what are the important outcomes for patients with TN is essential. The choice of standardized outcome measures allowing for consistent reporting in TN treatment will allow for comparison of studies and facilitate treatment choice for patients and clinicians thus, improving health outcomes and reducing health care cost. Competing Interests: This work was supported by the Trigeminal Neuralgia Association UK (TNAUK) and by the Rosetrees Trust (grant A2327). J.Z. undertook this work at UCL/UCLHT, who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centre funding scheme. The founding sources had no role in the study design, in the collection, analysis and interpretation of the data, in the writing of the report and in the decision to submit the article for publication. (© 2020 The Authors.) |
| Databáze: | MEDLINE |
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