Epidemiology, clinical features and diagnostic work-up of cystic neoplasms of the pancreas: Interim analysis of the prospective PANCY survey.

Autor: Pezzilli R; Department of Gastroenterology, San Carlo Hospital, Potenza, Italy. Electronic address: raffaele.pezzilli@gmail.com., Buscarini E; Gastroenterology and Endoscopy Unit, Maggiore Hospital, Crema, Italy., Pollini T; Pancreas Institute, Verona University, Verona, Italy., Bonamini D; Pancreas Institute, Verona University, Verona, Italy., Marchegiani G; Pancreas Institute, Verona University, Verona, Italy., Crippa S; Pancreatic Surgery Unit, Pancreas Translational & Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy., Belfiori G; Pancreatic Surgery Unit, Pancreas Translational & Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy., Sperti C; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy., Moletta L; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy., Pozza G; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy., De Nucci G; Gastroenterology and Endoscopy Unit, Rhodense Hospital, Milan, Italy., Manes G; Gastroenterology and Endoscopy Unit, Rhodense Hospital, Milan, Italy., Mandelli ED; Gastroenterology and Endoscopy Unit, Rhodense Hospital, Milan, Italy., Casadei R; Surgical Department, Polyclinic of Sant'Orsola, University of Bologna, Bologna, Italy., Ricci C; Surgical Department, Polyclinic of Sant'Orsola, University of Bologna, Bologna, Italy., Alicante S; Gastroenterology and Endoscopy Unit, Maggiore Hospital, Crema, Italy., Vattiato C; Gastroenterology and Endoscopy Unit, Maggiore Hospital, Crema, Italy., Carrara S; Humanitas Clinical and Research Center, IRCCS, Digestive Endoscopy Unit, Division Of Gastroenterology, Milan, Italy., Di Leo M; Humanitas Clinical and Research Center, IRCCS, Digestive Endoscopy Unit, Division Of Gastroenterology, Milan, Italy., Fabbri C; Unit of Gastroenterology and Digestive Endoscopy, Forlì-Cesena, Italy., Giovanelli S; Gastroenterology and Interventional Endoscopy Unit, Maggiore Hospital, Bologna, Italy., Barresi L; Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Highly Specialized Therapies), Palermo, Italy., Tacelli M; Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Highly Specialized Therapies), Palermo, Italy., Mirante VG; Gastroenterology and Endoscopy Unit, Baggiovara Hospital, University Hospital, Modena, Italy., Conigliaro R; Gastroenterology and Endoscopy Unit, Baggiovara Hospital, University Hospital, Modena, Italy., Antonini F; Gastroenterology and Digestive Endoscopy Unit, Augusto Murri Hospital, Polytechnic University of Marche, Fermo, Italy., Macarri G; Gastroenterology and Digestive Endoscopy Unit, Augusto Murri Hospital, Polytechnic University of Marche, Fermo, Italy., Frulloni L; Gastroenterology, Department of Medicine, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy., De Marchi G; Gastroenterology, Department of Medicine, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy., Sassatelli R; IRCCS Hospital, Reggio Emilia, Italy., Cecinato P; IRCCS Hospital, Reggio Emilia, Italy., Del Vecchio Blanco G; Unit of Gastroenterology, Department of Medicine, Tor Vergata University, Rome, Italy., Galli A; Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences, Florence, Italy., Pezzullo A; Department of Anesthesiological, Surgical and Emergency Sciences, University of Naples, Naples, Italy., Fantin A; Gastroenterology Unit, Padua, Italy., Graffeo M; Department of Internal Medicine, Gastroenterology and Endoscopy, Poliambulanza Hospital, Brescia, Italy., Frego M; Surgical Department, Ospedali Riuniti, Padua, Italy., Stillittano D; Digestive Endoscopy Unit, Desio Hospital, Milan, Italy., Monica F; Gastroenterology and Digestive Endoscopy, Cattinara Hospital, Cattinara, Trieste, Italy., Germanà B; Gastroenterology Unit, San Martino Hospital, Belluno, Italy., Capurso G; Digestive and Liver Disease Unit, S. Andrea Hospital, Rome, Italy., Quartini M; Gastroenterology Unit, Santa Maria Hospital, Terni, Italy., Veneroni L; Surgical Department, Infermi Hospital, Rimini, Italy., Cannizzaro R; Oncological Center, Aviano-Pordenone, Italy., Falconi M; Pancreatic Surgery Unit, Pancreas Translational & Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2020 May; Vol. 52 (5), pp. 547-554. Date of Electronic Publication: 2020 Feb 29.
DOI: 10.1016/j.dld.2020.02.003
Abstrakt: Introduction: A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines.
Methods: An online data sheet was built.
Results: Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up.
Conclusions: This prospective study offers a reliable real-life picture of the diagnostic work-up CPN.
(Copyright © 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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