Impact of ANCA-Associated Vasculitis on Outcomes of Hospitalizations for Goodpasture's Syndrome in the United States: Nationwide Inpatient Sample 2003-2014.

Autor: Thongprayoon C; Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Kaewput W; Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok 10400, Thailand., Boonpheng B; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA., Ungprasert P; Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand., Bathini T; Department of Internal Medicine, University of Arizona, Tucson, AZ 85721, USA., Srivali N; Department of Internal Medicine, St. Agnes Hospital, Baltimore, MD 21229, USA., Vallabhajosyula S; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA., Castaneda JL; Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Monga D; Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Kanduri SR; Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Medaura J; Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Cheungpasitporn W; Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Jazyk: angličtina
Zdroj: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2020 Mar 01; Vol. 56 (3). Date of Electronic Publication: 2020 Mar 01.
DOI: 10.3390/medicina56030103
Abstrakt: Background and objectives : Goodpasture's syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture's syndrome has been recognized, the impacts of ANCA vasculitis on mortality and resource utilization among patients with GS are unclear. Materials and Methods : We used the National Inpatient Sample to identify hospitalized patients with a principal diagnosis of GS from 2003 to 2014 in the database. The predictor of interest was the presence of ANCA-associated vasculitis. We tested the differences concerning in-hospital treatment and outcomes between GS patients with and without ANCA-associated vasculitis using logistic regression analysis with adjustment for other clinical characteristics. Results : A total of 964 patients were primarily admitted to hospital for GS. Of these, 84 (8.7%) had a concurrent diagnosis of ANCA-associated vasculitis. Hemoptysis was more prevalent in GS patients with ANCA-associated vasculitis. During hospitalization, GS patients with ANCA-associated required non-significantly more mechanical ventilation and non-invasive ventilation support, but non-significantly less renal replacement therapy and plasmapheresis than those with GS alone. There was no significant difference in in-hospital outcomes, including organ failure and mortality, between GS patients with and without ANCA-associated vasculitis. Conclusions : Our study demonstrated no significant differences between resource utilization and in-hospital mortality among hospitalized patients with coexistence of ANCA vasculitis and GS, compared to those with GS alone.
Databáze: MEDLINE