The Polyamine Putrescine Promotes Human Epidermal Melanogenesis.

Autor: Sridharan A; Skin Research Institute of Singapore, Agency for Science, Technology and Research, Biomedical Grove, Immunos, Singapore., Shi M; Skin Research Institute of Singapore, Agency for Science, Technology and Research, Biomedical Grove, Immunos, Singapore., Leo VI; Skin Research Institute of Singapore, Agency for Science, Technology and Research, Biomedical Grove, Immunos, Singapore., Subramaniam N; Skin Research Institute of Singapore, Agency for Science, Technology and Research, Biomedical Grove, Immunos, Singapore., Lim TC; Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Hospital and National University of Singapore, Kent Ridge Wing, Singapore., Uemura T; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan., Igarashi K; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan., Tien Guan ST; Skin Research Institute of Singapore, Agency for Science, Technology and Research, Biomedical Grove, Immunos, Singapore., Tan NS; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Nanyang Drive, Singapore., Vardy LA; Skin Research Institute of Singapore, Agency for Science, Technology and Research, Biomedical Grove, Immunos, Singapore; School of Biological Sciences, Nanyang Technological University, Nanyang Drive, Singapore. Electronic address: leah.vardy@sris.a-star.edu.sg.
Jazyk: angličtina
Zdroj: The Journal of investigative dermatology [J Invest Dermatol] 2020 Oct; Vol. 140 (10), pp. 2032-2040.e1. Date of Electronic Publication: 2020 Feb 28.
DOI: 10.1016/j.jid.2020.02.009
Abstrakt: Hyperpigmentary conditions can arise when melanogenesis in the epidermis is misregulated. Understanding the pathways underlying melanogenesis is essential for the development of effective treatments. Here, we report that a group of metabolites called polyamines are important in the control of melanogenesis in human skin. Polyamines are cationic molecules present in all cells and are essential for cellular function. We report that polyamine regulator ODC1 is upregulated in melanocytes from melasma lesional skin. We report that the polyamine putrescine can promote pigmentation in human skin explants and primary normal human epidermal melanocytes through induction of tyrosinase which is rate-limiting for the synthesis of melanin. Putrescine supplementation on normal human epidermal melanocytes results in the activation of polyamine catabolism, which results in increased intracellular H 2 O 2. Polyamine catabolism is also increased in human skin explants that have been treated with putrescine. We further report that inhibition of polyamine catabolism prevents putrescine-induced promotion of tyrosinase levels and pigmentation in normal human epidermal melanocytes, showing that polyamine catabolism is responsible for the putrescine induction of melanogenesis. Our data showing that putrescine promotes pigmentation has important consequences for hyperpigmented and hypopigmented conditions. Further understanding of how polyamines control epidermal pigmentation could open the door for the development of new therapeutics.
(Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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