Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement.

Autor:	Zborníková E; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.; Department of Analytical Chemistry, Faculty of Science, Charles University Prague, Hlavova 8, 128 43 Prague 2, Czech Republic., Gallo J; Department of Orthopedics, Faculty of Medicine and Dentistry, Palacký University Olomouc, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic., Večeřová R; Department of Microbiology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic., Bogdanová K; Department of Microbiology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic., Kolář M; Department of Microbiology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic., Vítovská D; Institute of Microbiology, Czech Academy of Sciences v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic., Do Pham DD; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic., Pačes O; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic., Mojr V; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic., Šanderová H; Institute of Microbiology, Czech Academy of Sciences v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic., Ulrichová J; Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic., Galandáková A; Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic., Čadek D; Department of Polymers, University of Chemistry and Technology Prague, Technická 5, Dejvice, 166 28 Praha 6, Czech Republic., Hrdlička Z; Department of Polymers, University of Chemistry and Technology Prague, Technická 5, Dejvice, 166 28 Praha 6, Czech Republic., Krásný L; Institute of Microbiology, Czech Academy of Sciences v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic., Rejman D; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2020 Feb 12; Vol. 5 (7), pp. 3165-3171. Date of Electronic Publication: 2020 Feb 12 (Print Publication: 2020).
DOI:	10.1021/acsomega.9b03072
Abstrakt:	Successful surgeries involving orthopedic implants depend on the avoidance of biofilm development on the implant surface during the early postoperative period. Here, we investigate the potential of novel antibacterial compounds-second-generation lipophosphonoxins (LPPOs II)-as additives to surgical bone cements. We demonstrate (i) excellent thermostability of LPPOs II, which is essential to withstand elevated temperatures during exothermic cement polymerization; (ii) unchanged tensile strength and elongation at the break properties of the composite cements containing LPPOs II compared to cements without additives; (iii) convenient elution kinetics on the order of days; and (iv) the strong antibiofilm activity of the LPPO II-loaded cements even against bacteria resistant to the medicinally utilized antibiotic, gentamicin. Thus, LPPOs II display promising potential as antimicrobial additives to surgical bone cements. Competing Interests: The authors declare no competing financial interest. (Copyright © 2020 American Chemical Society.)
Databáze:	MEDLINE
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