Divergent Roles of Inflammation in Skeletal Muscle Recovery From Injury.

Autor:	Howard EE; Department of Nutritional Sciences, University of Connecticut, Storrs, CT, United States.; Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, United States.; Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States., Pasiakos SM; Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, United States., Blesso CN; Department of Nutritional Sciences, University of Connecticut, Storrs, CT, United States., Fussell MA; Department of Nutritional Sciences, University of Connecticut, Storrs, CT, United States., Rodriguez NR; Department of Nutritional Sciences, University of Connecticut, Storrs, CT, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2020 Feb 13; Vol. 11, pp. 87. Date of Electronic Publication: 2020 Feb 13 (Print Publication: 2020).
DOI:	10.3389/fphys.2020.00087
Abstrakt:	A transient increase in local pro-inflammatory cytokine expression following skeletal muscle injury mediates the repair and regeneration of damaged myofibers through myogenesis. Regenerative capacity is diminished and muscle wasting occurs, however, when intramuscular inflammatory signaling is exceedingly high or persists chronically. An excessive and persistent inflammatory response to muscle injury may therefore impair recovery by limiting the repair of damaged tissue and triggering muscle atrophy. The concentration-dependent activation of different downstream signaling pathways by several pro-inflammatory cytokines in cell and animal models support these opposing roles of post-injury inflammation. Understanding these molecular pathways is essential in developing therapeutic strategies to attenuate excessive inflammation and accelerate functional recovery and muscle mass accretion following muscle damage. This is especially relevant given the observation that basal levels of intramuscular inflammation and the inflammatory response to muscle damage are not uniform across all populations, suggesting certain individuals may be more susceptible to an excessive inflammatory response to injury that limits recovery. This narrative review explores the opposing roles of intramuscular inflammation in muscle regeneration and muscle protein turnover. Factors contributing to an exceedingly high inflammatory response to damage and age-related impairments in regenerative capacity are also considered. (Copyright © 2020 Howard, Pasiakos, Blesso, Fussell and Rodriguez.)
Databáze:	MEDLINE
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