Obesity, adipose tissue, and bariatric surgery.
| Autor: | Frigolet ME; Laboratorio de Enfermedades Metabólicas, Hospital Infantil de México Federico Gómez, Ciudad de México, México., Dong-Hoon K; Department of Pharmacology, Korea University College of Medicine, Seúl, Corea del Sur, México., Canizales-Quinteros S; Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México.; Instituto Nacional de Medicina Genómica, Ciudad de México, México., Gutiérrez-Aguilar R; Laboratorio de Enfermedades Metabólicas, Hospital Infantil de México Federico Gómez, Ciudad de México, México.; División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México. |
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| Jazyk: | angličtina |
| Zdroj: | Boletin medico del Hospital Infantil de Mexico [Bol Med Hosp Infant Mex] 2020; Vol. 77 (1), pp. 3-14. |
| DOI: | 10.24875/BMHIM.19000115 |
| Abstrakt: | Obesity prevalence has increased in the last decades worldwide leading to metabolic complications, such as type 2 diabetes, steatosis, cardiovascular disease, among others; its development is influenced by genetic factors and environmental factors, such as intestinal microbiome. In Mexico, 33.3% of the adults present this disease. Obesity is defined as an excessive adipose tissue accumulation, provoking its dysfunction. Adipose tissue remodeling, which involves angiogenesis, hypoxia and inflammation, is implicated in the developing of obesity and metabolic modifications. Bariatric surgery is the most used and successful intervention to control morbid obesity, leading a maintained loss of weight and remission of some of its comorbidities as type 2 diabetes. Here, we review some of the molecular aspects of the metabolic changes provoked by bariatric surgery and its impact in weight loss and comorbidities remission. In summary, this article reviews the genetic aspects, microbiome and molecular facts (adipose tissue remodeling) that are involved in obesity development. In addition, some of the molecular aspects about bariatric surgery are described and the mechanisms that are regulated to control obesity and its comorbidities. (Copyright: © 2019 Permanyer.) |
| Databáze: | MEDLINE |
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