Comparative Assessment of Two Strategies for Interpreting Tumor Markers in Ascitic Effusions.

Autor:	Trapé J; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain jtrape@althaia.cat.; Facultat de Medicina, Universitat de Vic, Universitat Central de Catalunya, Vic, Spain., Sant F; Facultat de Medicina, Universitat de Vic, Universitat Central de Catalunya, Vic, Spain.; Department of Pathology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Montesinos J; Department of Oncology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Arnau A; Clinical Research Unit, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Sala M; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Figols C; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Franquesa J; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Esteve-Valverde E; Department of Internal Medicine Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Pérez R; Department of Internal Medicine Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Aligué J; Department of Internal Medicine Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Catot S; Department of Oncology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Casado E; Department of Oncology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Domenech M; Department of Oncology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Trapé-Ubeda J; Faculty of Pharmacy, Universitat de Barcelona, Barcelona, Spain., Bergós C; Service of Gynecology Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Vida F; Service of Gastroenterology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Sort P; Service of Gastroenterology, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Bonet M; Department of Internal Medicine Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Ruiz D; Department of Internal Medicine Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., González-Fernández C; Department of Laboratory Medicine, Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Ordeig J; Department of Internal Medicine Althaia Xarxa Assistencial Universitària de Manresa, Manresa, Spain., Molina R; Department of Clinical Biochemistry, Hospital Clínic, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	In vivo (Athens, Greece) [In Vivo] 2020 Mar-Apr; Vol. 34 (2), pp. 715-722.
DOI:	10.21873/invivo.11829
Abstrakt:	Background/aim: There are two strategies for the interpretation of tumor markers (TM) in fluid effusions: i) high cut-off and ii) fluid/serum ratio (F/S) and low cut-off. The objective of this study is to compare these two strategies and to determine whether diagnostic accuracy improves by the identification of possible false positives using Adenosine deaminase (ADA), C reactive protein (CRP) and % of polymorphonuclear cells (%PN). Patients and Methods: We studied 157 ascitic fluids, 74 of which were malignant. ADA, CRP and %PN were determined in ascitic fluid, and Carcinoembryonic antigen (CEA), Cancer antigen 72-4 (CA72-4), Cancer antigen CA19-9 and Cancer antigen 15-3 (CA15-3) in both fluid and serum. Results: The strategy of high cut-off showed 59.5% sensitivity at 100% specificity. The F/S strategy showed 75.7% sensitivity at 95.2% specificity. Subclassifying cases with ADA, CRP and %PN negative showed 67.5% sensitivity at 100% specificity for high cut-off and for the F/S strategy was 81.7% sensitivity at 98.7% specificity. Conclusion: The strategy of F/S with negative ADA, CRP and %PN allow the best interpretation for TM in the ascitic fluid. (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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