Effect of ovariectomy on proximal tibia metaphysis and lumbar vertebral body in common marmoset monkeys.

Autor: Schlumbohm C; German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany., Seidlová-Wuttke D; Department of Endocrinology, University Medical Center Göttingen, 37075 Göttingen, Germany., Fuchs E; German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Jazyk: angličtina
Zdroj: Primate biology [Primate Biol] 2019 Jul 12; Vol. 6 (2), pp. 65-73. Date of Electronic Publication: 2019 Jul 12 (Print Publication: 2019).
DOI: 10.5194/pb-6-65-2019
Abstrakt: This study aimed to investigate the effect of estrogen withdrawal on bone tissue in adult female marmoset monkeys. In a 1-year follow-up study we used quantitative computer tomography to measure total bone mineral density (BMD) of the proximal tibia and the second-last lumbar vertebral body (L5/L6) before and 1, 3, 6, and 12 months after ovariectomy. Body mass did not significantly change during the 1-year observation period. However, a significant decline of total BMD after ovariectomy was observed in the proximal tibia but not in L5/L6. In addition, regression analysis showed a significant positive relationship between BMD and body mass in both tibia and L5/L6. The results of our study support the idea that ovariectomized marmoset monkeys may serve as a model to investigate bone loss related to decline of estrogen production.
Competing Interests: Eberhard Fuchs is coordinating editor of the journal .
(Copyright: © 2019 Christina Schlumbohm et al.)
Databáze: MEDLINE
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