Effect of Sex Differences on Computed Tomography Findings in Adults With Cystic Fibrosis: A Multicenter Study.

Autor: Diab Cáceres L; Pulmonology Service, Hospital Universitario La Princesa, Madrid, Spain. Electronic address: layladch@gmail.com., Girón Moreno RM; Pulmonology Service, Hospital Universitario La Princesa, Madrid, Spain., García Castillo E; Pulmonology Service, Hospital Universitario La Princesa, Madrid, Spain., Pastor Sanz MT; Pulmonology Service, Hospital Universitario La Princesa, Madrid, Spain., Olveira C; Pulmonology Service, Hospital Regional Universitario de Málaga, Málaga, Spain., García Clemente M; Pulmonology Service, Hospital Central de Asturias, Oviedo, Spain., Nieto Royo R; Pulmonology Service, Hospital Universitario Ramón y Cajal, Madrid, Spain., Prados Sánchez C; Pulmonology Service, Hospital Universitario La Paz, Madrid, Spain., Caballero Sánchez P; Radiodiagnostic Service, Hospital Universitario La Princesa, Madrid, Spain., Olivera Serrano MJ; Radiodiagnostic Service, Hospital Universitario La Princesa, Madrid, Spain., Padilla Galo A; Pulmonology Service, Hospital Costa del Sol, Marbella, Spain., Nava Tomas E; Radiodiagnostic Service, Hospital Central de Asturias, Oviedo, Spain., Esteban Peris A; Radiodiagnostic Service, Hospital Universitario Ramón y Cajal, Madrid, Spain., Fernández Velilla M; Radiodiagnostic Service, Hospital Universitario La Paz, Madrid, Spain., Torres MI; Radiodiagnostic Service, Hospital Universitario La Paz, Madrid, Spain., Ancochea Bermúdez J; Pulmonology Service, Hospital Universitario La Princesa, Madrid, Spain.
Jazyk: English; Spanish; Castilian
Zdroj: Archivos de bronconeumologia [Arch Bronconeumol (Engl Ed)] 2021 Apr; Vol. 57 (4), pp. 256-263. Date of Electronic Publication: 2020 Feb 24.
DOI: 10.1016/j.arbres.2019.12.028
Abstrakt: Background: The survival of women with cystic fibrosis (CF) is lower than that of men by approximately 5 years. While various factors have been put forward to account for this discrepancy, no specific reasons have been established. Our hypothesis was that anatomical-structural involvement is more pronounced in women with CF than in men and that this is reflected in thoracic HRCT findings.
Material and Methods: We performed a prospective multicentre study, in which adult patients were consecutively included over 18 months. Chest HRCT was performed, and findings were scored by 2 thoracic radiologists using the modified Bhalla system. We also studied respiratory function, applied the CFQR 14+ questionnaire, and collected clinical variables.
Results: Of the 360 patients followed up in the participating units, 160 were eventually included. Mean age was 28 years, and 47.5% were women. The mean±SD global score on the modified Bhalla score was 13.7±3.8 in women and 15.2±3.8 in men (p=0.024). The highest scores were observed for sacculations, bronchial generations, and air trapping in women. Women had lower BMI, %FEV 1 , %FVC, and %DLCO. Similarly, the results for the respiratory domain in CFQR 14+ were worse in women, who also had more annual exacerbations.
Conclusions: This is the first study to provide evidence of the implication of sex differences in HRCT findings in patients with CF. Women with CF present a more severe form of the disease that results in more frequent exacerbations, poorer functional and nutritional outcomes, deterioration of quality of life, and greater structural damage.
(Copyright © 2020 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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