Molecular inflammation and oxidative stress are shared mechanisms involved in both myocardial infarction and periodontitis.

Autor: Díaz CM; Department of Oral Medicine and Periodontology, University of Seville, Sevilla, Spain., Bullon B; Department of Oral Medicine and Periodontology, University of Seville, Sevilla, Spain., Ruiz-Salmerón RJ; Heart Center, Virgen Macarena University Hospital, Sevilla, Spain., Fernández-Riejos P; Department of Clinical Biochemistry, Virgen Macarena University Hospital, Sevilla, Spain., Fernández-Palacín A; Department of Statistics, School of Medicine, University of Seville, Sevilla, Spain., Battino M; Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche-Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy.; Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo, Vigo, Spain.; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China., Cordero MD; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Center, University of Granada, Granada, Spain., Quiles JL; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Center, University of Granada, Granada, Spain.; College of Food Science and Technology, Northwest University, Xi'an, China., Varela-López A; Department of Physiology, Institute of Nutrition and Food Technology 'José Mataix Verdú', Biomedical Research Center, University of Granada, Granada, Spain., Bullón P; Department of Oral Medicine and Periodontology, University of Seville, Sevilla, Spain.
Jazyk: angličtina
Zdroj: Journal of periodontal research [J Periodontal Res] 2020 Aug; Vol. 55 (4), pp. 519-528. Date of Electronic Publication: 2020 Feb 27.
DOI: 10.1111/jre.12739
Abstrakt: Background and Objective: Our aims were to improve the understanding of the pathogenic relationship between cardiovascular diseases and periodontitis and to generate new perspectives in the prevention and treatment of acute myocardial infarction (AMI) and periodontitis. The present study evaluates possible differences in inflammation, oxidative stress, and autophagy markers among subject suffering AMI, periodontitis, or both, to explore possible common pathogenic mechanisms.
Material and Methods: A total of 260 subjects were enrolled in the study: 106 subjects that survived to a first AMI (AMI group) and 154 subjects had no cardiac events in their clinical record (control group). A questionnaire was used to assess age, height, weight, blood pressure, and heart rate. The clinical probing depth, clinical attachment loss, number of remaining teeth, and average number of sites with bleeding on probing were assessed. Lipid peroxidation and protein levels of phosphorylated AMP-activated protein kinase (p-AMPK) and microtubule-associated proteins 1A/1B-light chain 3-II (LC3-II) were determined in isolated peripheral blood mononuclear cells by thiobarbituric acid reactive substances (TBARS) assay and Western blot, respectively. Plasma levels of interleukin-1β were determined using a commercial ELISA kit. All the obtained variables were compared between subjects suffering an AMI with or without periodontitis and control subject periodontal healthy or with periodontitis.
Results: A higher proportion of subjects suffering AMI + periodontitis than only AMI (without periodontitis) was found. Higher levels of TBARS were found in subjects with periodontitis than in subjects without periodontitis in both AMI and control subjects. Positive correlations between IL-1β levels and TBARS and between IL-1β levels and LC3-II were found only in control subjects.
Conclusion: Results from the present study are consistent with the suggestion of periodontitis as a potential risk factor for AMI. Periodontitis association with circulating lipid peroxides in both AMI and control subjects were found. The absence of differences in IL-1β levels between AMI subjects (only AMI vs AMI + periodontitis) suggests that oxidative stress could be the main pathogenic link between AMI and periodontitis.
(© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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