| Autor: |
Yan PG; Department of Gastroenterology, Peking Union Medical College Hospital, Beijing 100730, China.; Key Laboratory of Gut Microbiota Translational Medicine Research, Chinese Academy of Medical Sciences, Beijing 100730, China., Li JN; Department of Gastroenterology, Peking Union Medical College Hospital, Beijing 100730, China.; Key Laboratory of Gut Microbiota Translational Medicine Research, Chinese Academy of Medical Sciences, Beijing 100730, China. |
| Jazyk: |
angličtina |
| Zdroj: |
Chinese medical journal [Chin Med J (Engl)] 2020 Apr 05; Vol. 133 (7), pp. 834-841. |
| DOI: |
10.1097/CM9.0000000000000718 |
| Abstrakt: |
The human gastrointestinal tract accommodates an entire micro-environment for divergent physiologic processes, the dysbiosis of this micro-ecology has a strong inter-action with the pathogenesis of inflammatory bowel disease (IBD). In the past few years, with the advances in the understanding of microbiome, its metabolites and further application of next generation sequencing, analysis of dynamic alteration of gut micro-environment was realized, which provides numerous information beyond simple microbiota structure or metabolites differences under chronic colitis status. The subsequent intervention strategies targeting the modulation of intestinal micro-environment have been explored as a potential therapy. In this review, we will summarize the recent knowledge about multi-dimensional dysbiosis, the inter-action between fungus and bacteria under inflamed mucosa, and the clinical application of probiotics and fecal microbiota transplantation as a promising therapeutic approach in IBD. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
