Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial.

Autor: Angeles DM; Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, USA. dangeles@llu.edu.; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA. dangeles@llu.edu., Boskovic DS; Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, USA., Tan JC; Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, USA., Shih W; School of Public Health, Loma Linda Univeristy, Loma Linda, CA, USA., Hoch E; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Forde D; School of Nursing, University of California, San Francisco, CA, USA., Phillips RM; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Hopper A; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Deming DD; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Goldstein M; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Truong G; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Febre A; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Pegis P; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Lavery A; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Kadri M; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Banerji A; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Mousselli I; Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, USA., Farha V; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA., Fayard E; Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.; Loma Linda University Children's Hospital, Loma Linda, CA, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2020 Jun; Vol. 40 (6), pp. 888-895. Date of Electronic Publication: 2020 Feb 26.
DOI: 10.1038/s41372-020-0634-0
Abstrakt: Objective: To examine the effects of 30% oral dextrose on biochemical markers of pain, adenosine triphosphate (ATP) degradation, and oxidative stress in preterm neonates experiencing a clinically required heel lance.
Study Design: Utilizing a prospective study design, preterm neonates that met study criteria (n = 169) were randomized to receive either (1) 30% oral dextrose, (2) facilitated tucking, or (3) 30% oral dextrose and facilitated tucking 2 min before heel lance. Plasma markers of ATP degradation (hypoxanthine, uric acid) and oxidative stress (allantoin) were measured before and after the heel lance. Pain was measured using the premature infant pain profile-revised (PIPP-R).
Results: Oral dextrose, administered alone or with facilitated tucking, did not alter plasma markers of ATP utilization and oxidative stress.
Conclusion: A single dose of 30% oral dextrose, given before a clinically required heel lance, decreased signs of pain without increasing ATP utilization and oxidative stress in premature neonates.
Databáze: MEDLINE
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