Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle.

Autor:	Wang K; Department of Immunology, Harvard Medical School, Boston, MA 02115.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115., Yaghi OK; Department of Immunology, Harvard Medical School, Boston, MA 02115.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115., Spallanzani RG; Department of Immunology, Harvard Medical School, Boston, MA 02115.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115., Chen X; Department of Immunology, Harvard Medical School, Boston, MA 02115.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115., Zemmour D; Department of Immunology, Harvard Medical School, Boston, MA 02115.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115., Lai N; Department of Immunology, Harvard Medical School, Boston, MA 02115., Chiu IM; Department of Immunology, Harvard Medical School, Boston, MA 02115., Benoist C; Department of Immunology, Harvard Medical School, Boston, MA 02115; cbdm@hms.harvard.edu.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115., Mathis D; Department of Immunology, Harvard Medical School, Boston, MA 02115; cbdm@hms.harvard.edu.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 10; Vol. 117 (10), pp. 5402-5408. Date of Electronic Publication: 2020 Feb 26.
DOI:	10.1073/pnas.1922559117
Abstrakt:	A distinct population of Foxp3 + CD4 + regulatory T (Treg) cells promotes repair of acutely or chronically injured skeletal muscle. The accumulation of these cells depends critically on interleukin (IL)-33 produced by local mesenchymal stromal cells (mSCs). An intriguing physical association among muscle nerves, IL-33 + mSCs, and Tregs has been reported, and invites a deeper exploration of this cell triumvirate. Here we evidence a striking proximity between IL-33 + muscle mSCs and both large-fiber nerve bundles and small-fiber sensory neurons; report that muscle mSCs transcribe an array of genes encoding neuropeptides, neuropeptide receptors, and other nerve-related proteins; define muscle mSC subtypes that express both IL-33 and the receptor for the calcitonin-gene-related peptide (CGRP); and demonstrate that up- or down-tuning of CGRP signals augments or diminishes, respectively, IL-33 production by muscle mSCs and later accumulation of muscle Tregs. Indeed, a single injection of CGRP induced much of the genetic program elicited in mSCs early after acute skeletal muscle injury. These findings highlight neural/stromal/immune-cell crosstalk in tissue repair, suggesting future therapeutic approaches. Competing Interests: The authors declare no competing interest.
Databáze:	MEDLINE
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