Curcumin Preparations Can Improve Flow-Mediated Dilation and Endothelial Function: A Meta-Analysis.
| Autor: | Changal KH; Cardiovascular Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA, khalid.changal@utoledo.edu., Khan MS; Internal Medicine, Mercy Health St. Vincent Medical Center, Toledo, Ohio, USA., Bashir R; Institute of Dental Studies and Technologies, Chaudhary Charan Singh University, Meerut, India., Sheikh MA; Promedica Toledo Hospital, Toledo, Ohio, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Complementary medicine research [Complement Med Res] 2020; Vol. 27 (4), pp. 272-281. Date of Electronic Publication: 2020 Feb 26. |
| DOI: | 10.1159/000506180 |
| Abstrakt: | Introduction: Endothelial dysfunction is an early marker of atherosclerosis. Flow-mediated dilation (FMD), measured by ultrasonography, is used to noninvasively assess endothelial dysfunction. Preparations of curcumin, a naturally occurring pigment found in turmeric, may improve FMD and thus endothelial dysfunction. We did a systematic review and meta-analysis to analyze the effect of curcumin preparations on endothelial dysfunction. Methods: Five randomized clinical trials met the inclusion criteria for meta-analysis. The primary outcome was an improvement in FMD, as measured at brachial artery, after supplementations with curcumin preparations compared to the control group. Standardized mean difference and Hedges' g were used for effect size (ES) measurement. An ES of 0.2-0.5 is considered small, 0.5-0.8 is medium, and more than 0.8 is large. Publication bias was studied too. Results: We found supplementation with curcumin preparations had an overall ES (standard difference in means) of 1.379 (95% CI 0.485-2.274, p = 0.003) on FMD. The overall Hedges' g was 1.353 (95% CI 0.47-2.235, p = 0.03). This analysis suggests a positive and large ES of curcumin preparations on FMD using a random effect model. Smokers had a smaller increase in FMD compared to nonsmokers (ES 0.379 vs. 1.639, p = 0.034). Conclusion: This meta-analysis of 5 randomized clinical trials indicates a significant effect of curcumin preparations to increase the FMD compared to placebo and thus endothelial function. This effect is not strongly noticed in smokers. (© 2020 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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