Phase-Specific Microstimulation Differentially Modulates Beta Oscillations and Affects Behavior.

Autor:	Peles O; Department of Medical Neurobiology, Institute of Medical Research-Israel Canada, The Hebrew University-Hadassah Medical School, Jerusalem 9112102, Israel; Edmond and Lily Safra Centre for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel. Electronic address: oren.peles@mail.huji.ac.il., Werner-Reiss U; Department of Medical Neurobiology, Institute of Medical Research-Israel Canada, The Hebrew University-Hadassah Medical School, Jerusalem 9112102, Israel; Edmond and Lily Safra Centre for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel., Bergman H; Department of Medical Neurobiology, Institute of Medical Research-Israel Canada, The Hebrew University-Hadassah Medical School, Jerusalem 9112102, Israel; Edmond and Lily Safra Centre for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel., Israel Z; Department of Neurosurgery, Hadassah University Hospital, Jerusalem 9112102, Israel., Vaadia E; Department of Medical Neurobiology, Institute of Medical Research-Israel Canada, The Hebrew University-Hadassah Medical School, Jerusalem 9112102, Israel; Edmond and Lily Safra Centre for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2020 Feb 25; Vol. 30 (8), pp. 2555-2566.e3.
DOI:	10.1016/j.celrep.2020.02.005
Abstrakt:	It is widely accepted that Beta-band oscillations play a role in sensorimotor behavior. To further explore this role, we developed a hybrid platform to combine neural operant conditioning and phase-specific intracortical microstimulation (ICMS). We trained monkeys, implanted with 96 electrode arrays in the motor cortex, to volitionally enhance local field potential (LFP) Beta-band (20-30 Hz) activity at selected sites using a brain-machine interface. We find that Beta oscillations of LFP and single-unit spiking activity increase dramatically with brain-machine interface training and that pre-movement Beta power is anti-correlated with task performance. We also find that phase-specific ICMS modulates the power and phase of oscillations, shifting local networks between oscillatory and non-oscillatory states. Furthermore, ICMS induces phase-dependent effects in animal reaction times and success rates. These findings contribute to unraveling the functional role of cortical oscillations and to the future development of clinical tools for ameliorating abnormal neuronal activities in brain disease. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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