Histomorphometric evaluation of the rat kidney submitted to warm ischemia and the protective effect of resveratrol.

Autor: Buys-Gonçalves GF; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Sampaio FJB; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Silva MEM; Department of Veterinary Medicine, Educational Foundation Serra Dos Órgãos, Teresópolis, Brazil., Pereira-Sampaio MA; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Morphology, Fluminense Federal University, Niteroi, Brazil., De Souza DB; Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: desouza.db@gmail.com.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2020 Oct; Vol. 220 (4), pp. 1119-1123. Date of Electronic Publication: 2020 Feb 19.
DOI: 10.1016/j.amjsurg.2020.02.025
Abstrakt: Background: The objective of this study is to quantitatively evaluate the protective effects of resveratrol for using during renal warm ischemia.
Methods: Rats were allocated into 4 groups: Sham, Sham Resveratrol, Ischemia, Ischemia Resveratrol. Sham Resveratrol and Ischemia Resveratrol received resveratrol before surgery. Ischemia and Ischemia Resveratrol had renal vessels clamped. Animals were euthanized four weeks after. Serum urea and creatinine were measured. Renal weight and volume, cortex-non-cortex areas ratio, cortical volume, glomerular volumetric density, volume-weighted mean glomerular volume and number of glomeruli per kidney were evaluated.
Results: Serum urea in Ischemia increased by 10.4% compared to Sham and no differences were observed among Ischemia Resveratrol and sham groups. The glomerular volumetric density and number of glomeruli of Ischemia were lower than Sham but Ischemia Resveratrol had no difference compared to sham groups.
Conclusions: Preoperative administration of resveratrol has renoprotective effects, preventing the glomerular number reduction observed in warm ischemia.
Competing Interests: Declaration of competing interest The authors declare that there is no conflict of interest.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: