qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients.

Autor:	Prasetya H; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Ramos LA; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Epema T; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Treurniet KM; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Emmer BJ; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands., van den Wijngaard IR; Department of Neurology, Haaglanden Medical Center, the Hague, the Netherlands.; Department of Neurology, Leiden University Medical Centers, Leiden, the Netherlands., Zhang G; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Kappelhof M; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Berkhemer OA; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Radiology, Maastricht University Medical Center and Cardiovascular Research Institute, Maastricht, the Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., Yoo AJ; Division of Neurointervention, Texas Stroke Institute, Dallas, TX, USA., Roos YB; Department of Neurology, Amsterdam University Medical Centers, Amsterdam, the Netherlands., van Oostenbrugge RJ; Department of Neurology, Maastricht University Medical Center and Cardiovascular Research Institute, Maastricht, the Netherlands., Dippel DW; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands., van Zwam WH; Department of Radiology, Maastricht University Medical Center and Cardiovascular Research Institute, Maastricht, the Netherlands., van der Lugt A; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands., de Mol BA; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Majoie CB; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Bavel EV; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Marquering HA; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2021 Feb; Vol. 16 (2), pp. 207-216. Date of Electronic Publication: 2020 Feb 25.
DOI:	10.1177/1747493020909632
Abstrakt:	Background: The Thrombolysis in Cerebral Infarction (TICI) scale is an important outcome measure to evaluate the quality of endovascular stroke therapy. The TICI scale is ordinal and observer-dependent, which may result in suboptimal prediction of patient outcome and inconsistent reperfusion grading. Aims: We present a semi-automated quantitative reperfusion measure (quantified TICI (qTICI)) using image processing techniques based on the TICI methodology. Methods: We included patients with an intracranial proximal large vessel occlusion with complete, good quality runs of anteroposterior and lateral digital subtraction angiography from the MR CLEAN Registry. For each vessel occlusion, we identified the target downstream territory and automatically segmented the reperfused area in the target downstream territory on final digital subtraction angiography. qTICI was defined as the percentage of reperfused area in target downstream territory. The value of qTICI and extended TICI (eTICI) in predicting favorable functional outcome (modified Rankin Scale 0-2) was compared using area under receiver operating characteristics curve and binary logistic regression analysis unadjusted and adjusted for known prognostic factors. Results: In total, 408 patients with M1 or internal carotid artery occlusion were included. The median qTICI was 78 (interquartile range 58-88) and 215 patients (53%) had an eTICI of 2C or higher. qTICI was comparable to eTICI in predicting favorable outcome with area under receiver operating characteristics curve of 0.63 vs. 0.62 (P = 0.8) and 0.87 vs. 0.86 (P = 0.87), for the unadjusted and adjusted analysis, respectively. In the adjusted regression analyses, both qTICI and eTICI were independently associated with functional outcome. Conclusion: qTICI provides a quantitative measure of reperfusion with similar prognostic value for functional outcome to eTICI score.
Databáze:	MEDLINE
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