Presence of the protein indoleamine 2,3-dioxygenase (IDO) in the maternal-fetal interface of the yolk sac placenta of blue shark, Prionace glauca.

Autor: Salmon T; Sector of Anatomy, Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Brazil. Electronic address: salmonthierry@hotmail.com., Bruno CEM; Sector of Anatomy, Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Brazil., de Amorim AF; APTA Center for Marine Fish, Fisheries Institute, APTA, SAA, SP, Brazil., Kfoury Junior JR; Sector of Anatomy, Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Fish & shellfish immunology [Fish Shellfish Immunol] 2020 May; Vol. 100, pp. 256-260. Date of Electronic Publication: 2020 Feb 22.
DOI: 10.1016/j.fsi.2020.02.051
Abstrakt: Indoleamine 2 3-dioxygenase (IDO) is a protein usually described in mammals, which, among other functions, participates in the maternal-fetal tolerance process. The blue-shark, Prionace glauca (Linnaeus, 1758) is a viviparous placentary species in which the yolk sac develops during the pregnancy, turning into a placenta for matrotrophic nutrition of the embryo. The purpose of this study was to investigate the expression of IDO in the P. glauca maternal-fetal interface along three gestation phases and describe its distribution and the meaning of its presence. The results showed IDO labelling during the yolk sac/placenta development in the ectoderm on the three development phases and in the endoderm at the two first phases. In the uterine epithelium, IDO was observed in the last two phases. These interface tissues are major contact areas between the mother and the semiallogeneic conceptus and this relation could induce an immunological response against the fetus. Therefore, the presence of IDO may indicate that it could have a similar role in the mechanism of maternal-fetal tolerance in the P. glauca placental interface, as described in eutherian mammals.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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