Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia.

Autor: Mourão LC; Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: luizacmourao@hotmail.com., Medeiros CMP; Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: camilapantuzzo@gmail.com., Cardoso-Oliveira GP; Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: gustavopcdom92@hotmail.com., Roma PMDS; Department of Physics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: paula.magda.roma@hotmail.com., Aboobacar JDSS; Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: jamilaaboobacar@gmail.com., Rodrigues BCM; Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: carolina.rodrigues2016@outlook.com., Agero U; Department of Physics, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: bira@ufmg.br., Fontes CJF; School of Medical Sciences, Universidade Federal de Mato Grosso, Cuiabá, MT, 78060-900, Brazil. Electronic address: corfontes@gmail.com., Braga ÉM; Department of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address: embraga@icb.ufmg.br.
Jazyk: angličtina
Zdroj: Microbes and infection [Microbes Infect] 2020 Sep; Vol. 22 (8), pp. 379-383. Date of Electronic Publication: 2020 Feb 22.
DOI: 10.1016/j.micinf.2020.02.003
Abstrakt: Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that anti-RBC IgG and IgM are increased in anemic patients with acute vivax malaria. Furthermore, both antibodies are able to decrease the deformability of nRBCs, but only IgG can induce in vitro erythrophagocytosis. Such effects are enhanced in type O erythrocytes, suggesting that individuals from this blood group infected with P. vivax malaria may be more susceptible to develop anemia.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interests.
(Copyright © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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